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Multicenter Study
. 2018 Jan;60(1):36-43.
doi: 10.1097/JOM.0000000000001217.

Occupational UV-Exposure is a Major Risk Factor for Basal Cell Carcinoma: Results of the Population-Based Case-Control Study FB-181

Jochen Schmitt  1 , Eva Haufe, Freya Trautmann, Hans-Joachim Schulze, Peter Elsner, Hans Drexler, Andrea Bauer, Stephan Letzel, Swen Malte John, Manigé Fartasch, Thomas Brüning, Andreas Seidler, Susanne Dugas-Breit, Michal Gina, Wobbeke Weistenhöfer, Klaus Bachmann, Ilka Bruhn, Berenice Mareen Lang, Sonja Bonness, Jean Pierre Allam, William Grobe, Thoralf Stange, Stephan Westerhausen, Peter Knuschke, Marc Wittlich, Thomas Ludwig Diepgen; FB 181 Study Group
Affiliations
Multicenter Study

Occupational UV-Exposure is a Major Risk Factor for Basal Cell Carcinoma: Results of the Population-Based Case-Control Study FB-181

Jochen Schmitt et al. J Occup Environ Med. 2018 Jan.

Abstract

Objective: The aim of this study was to investigate the role of occupational and nonoccupational ultraviolet (UV)-exposure concerning the development of basal cell carcinoma (BCC).

Methods: We undertook a population-based multicenter case-control study. Patients with first incident BCC (n = 836) were propensity score matched by age and sex to controls without skin cancer (n = 836). Sociodemographic characteristics, clinical characteristics, and lifetime UV-exposure were assessed by trained investigators. The differential estimation of occupational and nonoccupational UV-exposure dosages was based on validated instruments and established reference values. Associations were assessed using multivariable-adjusted conditional logistic regression models.

Results: Individuals with high levels of occupational UV-exposure were at significantly increased BCC-risk compared with individuals with low [odds ratio (OR) 1.84; 95% confidence interval (95% CI) 1.19 to 2.83 and moderate (OR 1.97; 95% CI 1.20 to 3.22) occupational UV-exposure. Nonoccupational UV-exposure was not independently associated with BCC.

Conclusion: Skin cancer prevention strategies should be expanded to the occupational setting.

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