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. 2018 Jan 14;32(2):267-270.
doi: 10.1097/QAD.0000000000001680.

Toll-like receptor 9 polymorphism is associated with increased Epstein-Barr virus and Cytomegalovirus acquisition in HIV-exposed infants

Kristin Beima-Sofie  1 , Dalton Wamalwa  2 , Elizabeth Maleche-Obimbo  2 , Jairam R Lingappa  1   3   4 , Romel Mackelprang  1 , Soren Gantt  5 , Grace John-Stewart  1   3   4   6 , Corey Casper  1   3   7 , Jennifer A Slyker  1   6
Affiliations

Toll-like receptor 9 polymorphism is associated with increased Epstein-Barr virus and Cytomegalovirus acquisition in HIV-exposed infants

Kristin Beima-Sofie et al. AIDS. .

Abstract

: Polymorphisms in the Toll-like receptor 9 1635 locus have been associated with HIV-1 acquisition and progression. Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) acquisition were compared between Kenyan HIV-exposed infants by 1635 genotype. Having one or more copies of the 1635A allele was associated with increased CMV acquisition in HIV-infected infants (42 vs. 11%, P = 0.03) and increased risk of EBV acquisition in HIV-exposed uninfected infants (hazard ratio = 4.2, P = 0.02) compared with 1635GG. In addition, 1635A was associated with 0.4 log10 copies/ml lower median EBV levels in HIV-infected infants (P = 0.03). These data suggest a potentially important role for this locus in primary herpesvirus infection.

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