Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Jan 14;32(2):267-270.
doi: 10.1097/QAD.0000000000001680.

Toll-like receptor 9 polymorphism is associated with increased Epstein-Barr virus and Cytomegalovirus acquisition in HIV-exposed infants

Kristin Beima-Sofie  1 , Dalton Wamalwa  2 , Elizabeth Maleche-Obimbo  2 , Jairam R Lingappa  1   3   4 , Romel Mackelprang  1 , Soren Gantt  5 , Grace John-Stewart  1   3   4   6 , Corey Casper  1   3   7 , Jennifer A Slyker  1   6
Affiliations

Toll-like receptor 9 polymorphism is associated with increased Epstein-Barr virus and Cytomegalovirus acquisition in HIV-exposed infants

Kristin Beima-Sofie et al. AIDS. .

Abstract

: Polymorphisms in the Toll-like receptor 9 1635 locus have been associated with HIV-1 acquisition and progression. Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) acquisition were compared between Kenyan HIV-exposed infants by 1635 genotype. Having one or more copies of the 1635A allele was associated with increased CMV acquisition in HIV-infected infants (42 vs. 11%, P = 0.03) and increased risk of EBV acquisition in HIV-exposed uninfected infants (hazard ratio = 4.2, P = 0.02) compared with 1635GG. In addition, 1635A was associated with 0.4 log10 copies/ml lower median EBV levels in HIV-infected infants (P = 0.03). These data suggest a potentially important role for this locus in primary herpesvirus infection.

PubMed Disclaimer

References

    1. Beima-Sofie KM, Bigham AW, Lingappa JR, Wamalwa D, Mackelprang RD, Bamshad MJ, et al. Toll-like receptor variants are associated with infant HIV-1 acquisition and peak plasma HIV-1 RNA level. Aids. 2013;27(15):2431–2439. - PMC - PubMed
    1. Bochud PY, Hersberger M, Taffe P, Bochud M, Stein CM, Rodrigues SD, et al. Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infection. Aids. 2007;21(4):441–446. - PubMed
    1. Freguja R, Gianesin K, Del Bianco P, Malacrida S, Rampon O, Zanchetta M, et al. Polymorphisms of innate immunity genes influence disease progression in HIV-1-infected children. Aids. 2012;26(6):765–768. - PubMed
    1. Mackelprang RD, Bigham AW, Celum C, de Bruyn G, Beima-Sofie K, John-Stewart G, et al. Toll-like receptor polymorphism associations with HIV-1 outcomes among sub-Saharan Africans. J Infect Dis. 2014;209(10):1623–1627. - PMC - PubMed
    1. Pine SO, McElrath MJ, Bochud PY. Polymorphisms in toll-like receptor 4 and toll-like receptor 9 influence viral load in a seroincident cohort of HIV-1-infected individuals. Aids. 2009;23(18):2387–2395. - PMC - PubMed

Substances