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. 2017 Nov 5;9(11):1217.
doi: 10.3390/nu9111217.

Pediatric Chronic Intestinal Failure in Italy: Report from the 2016 Survey on Behalf of Italian Society for Gastroenterology, Hepatology and Nutrition (SIGENP)

Antonella Diamanti  1 , Teresa Capriati  2 , Paolo Gandullia  3 , Grazia Di Leo  4 , Antonella Lezo  5 , Laura Lacitignola  6 , Maria Immacolata Spagnuolo  7 , Simona Gatti  8 , Lorenzo D'Antiga  9 , Giovanna Verlato  10 , Paola Roggero  11 , Sergio Amarri  12 , Maria Elisabetta Baldassarre  13 , Francesco Cirillo  14 , Domenica Elia  15 , Renata Boldrini  16 , Angelo Campanozzi  17 , Carlo Catassi  18 , Marina Aloi  19 , Claudio Romano  20 , Manila Candusso  21 , Nicola Cecchi  22 , Tommaso Bellini  23 , Elaine Tyndall  24 , Fabio Fusaro  25 , Tamara Caldaro  26 , Daniele Alberti  27 , Piergiorgio Gamba  28 , Mario Lima  29 , Pietro Bagolan  30 , Jean De Ville de Goyet  31 , Luigi Dall'Oglio  32 , Marco Spada  33   34 , Francesca Grandi  35
Affiliations

Pediatric Chronic Intestinal Failure in Italy: Report from the 2016 Survey on Behalf of Italian Society for Gastroenterology, Hepatology and Nutrition (SIGENP)

Antonella Diamanti et al. Nutrients. .

Abstract

Background: Intestinal failure (IF) is the reduction in functioning gut mass below the minimal level necessary for adequate digestion and absorption of nutrients and fluids for weight maintenance in adults or for growth in children. There is a paucity of epidemiologic data on pediatric IF. The purpose of this study was to determine the prevalence, incidence, regional distribution and underlying diagnosis of pediatric chronic IF (CIF) requiring home parenteral nutrition (HPN) in Italy.

Methods: Local investigators were selected in 19 Italian centers either of reference for pediatric HPN or having pediatric gastroenterologists or surgeons on staff and already collaborating with the Italian Society for Pediatric Gastroenterology, Hepatology and Nutrition with regard to IF. Data requested in this survey for children at home on Parenteral Nutrition (PN) on 1 December 2016 included patient initials, year of birth, gender, family's place of residence and underlying diagnosis determining IF.

Results: We recorded 145 CIF patients on HPN aged ≤19 years. The overall prevalence was 14.12/million inhabitants (95% CI: 9.20-18.93); the overall incidence was 1.41/million inhabitant years (95% CI: 0.53-2.20).

Conclusion: Our survey provides new epidemiological data on pediatric CIF in Italy; these data may be quantitatively useful in developing IF care strategy plans in all developed countries.

Keywords: children; home parenteral nutrition; intestinal failure.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Regional prevalence.
Figure 2
Figure 2
Initiation of home parenteral nutrition programs.
Figure 3
Figure 3
Prevalence for age (A), incidence for age (B), and prevalence for gender (C).
Figure 4
Figure 4
Indications for home parenteral nutrition programs. (A) Prevalence of primary and non-primary digestive diseases. (B) Etiology of primary digestive diseases. (C) Etiology of non-primary digestive diseases.
Figure 5
Figure 5
Indications for home parenteral nutrition programs in primary digestive diseases. (A) Etiology of mucosal diseases. (B) Etiology of motility disorders. (C) Etiology of short bowel syndrome.
See this image and copyright information in PMC

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