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. 2017 Sep 20;8(46):81195-81203.
doi: 10.18632/oncotarget.21092. eCollection 2017 Oct 6.

Clinical characteristics and prognosis of acute myocardial infarction in young smokers and non-smokers (≤ 45 years): a systematic review and meta-analysis

Yuqi Liu #  1 , Tianwen Han #  1 , Ming Gao #  2 , Jinwen Wang  3 , Fang Liu  3 , Shanshan Zhou  1 , Yundai Chen  1
Affiliations

Clinical characteristics and prognosis of acute myocardial infarction in young smokers and non-smokers (≤ 45 years): a systematic review and meta-analysis

Yuqi Liu et al. Oncotarget. .

Abstract

The effect of smoking on the prognosis of young patients with acute myocardial infarction (AMI) is inconclusive. We enrolled 2188 young AMI patients (≤ 45 years) from the cardiac center of the Chinese PLA General Hospital and Anzhen Hospital and analyzed their clinical characteristics and prognosis. We also searched the PubMed, EMBASE, and Cochrane Central Register of Controlled Trials electronic databases for January 2001 to March 2017 and considered for inclusion in a meta-analysis those clinical trials that compared prognoses of young smokers and non-smokers with AMI. The proportion of males and alcohol users was higher in young AMI smokers than in non-smokers; the proportion of hypertension was slightly lower. There was no difference in medical treatment between smokers and non-smokers. No differences were evident between smokers and non-smokers regarding in-hospital cardiac events and major adverse cardiovascular events on follow-up, including incidence of stroke. For young AMI patients, smoking did not lead to poorer prognosisin comparison with not smoking. This "smoker's paradox" needs to be confirmed by more randomized controlled multicenter prospective clinical trials.

Keywords: AMI; meta-analysis; prognosis; smoking; young.

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Conflict of interest statement

CONFLICTS OF INTEREST None.

Figures

Figure 1
Figure 1. The incidence of in-hospital cardiac events compared between young smokers and non-smokers
3.4% (87/2496) in smokers compared with 5.7% (52/910) in non-smokers (OR, 0.48; 95% CI, 0.14–1.61; P 0.235).
Figure 2
Figure 2. The incidence of MACEs between young smokers and non-smokers
9.8% (270/2755) in smokers compared with 9.0% (103/1140) in non-smokers (OR, 1.45; 95% CI, 0.90–2.32; P 0.123)
Figure 3
Figure 3. Flow diagram showing the number of citations identified, retrieved, extracted, and included in the final analysis
See this image and copyright information in PMC

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