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Review
. 2017 Aug 11;8(46):81591-81603.
doi: 10.18632/oncotarget.20189. eCollection 2017 Oct 6.

Porphyrin photosensitizers in photodynamic therapy and its applications

Jiayuan Kou  1   2 , Dou Dou  3 , Liming Yang  1
Affiliations
Review

Porphyrin photosensitizers in photodynamic therapy and its applications

Jiayuan Kou et al. Oncotarget. .

Abstract

In 1841, the extraction of hematoporphyrin from dried blood by removing iron marked the birth of the photosensitizer. The last twenty years has witnessed extensive research in the application of photodynamic therapy (PDT) in tumor-bearing (or other diseases) animal models and patients. The period has seen development of photosensitizers from the first to the third generation, and their evolution from simple to more complex entities. This review focuses on porphyrin photosensitizers and their effect on tumors, mediated via several pathways involved in cell necrosis, apoptosis or autophagic cell death, and the preventive and therapeutic application of PDT against atherosclerosis.

Keywords: application; photodynamic therapy; porphyrin photosensitizers; tumor.

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Conflict of interest statement

CONFLICTS OF INTEREST The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1. Scheme of photosensitizer activating and ROS producing involved in PDT
See this image and copyright information in PMC

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