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Review
. 2017 Sep 14;8(46):81649-81661.
doi: 10.18632/oncotarget.20887. eCollection 2017 Oct 6.

Oxidative stress-induced diseases and tea polyphenols

Xiangbing Mao  1   2 , Changsong Gu  1   2 , Daiwen Chen  1   2 , Bing Yu  1   2 , Jun He  1   2
Affiliations
Review

Oxidative stress-induced diseases and tea polyphenols

Xiangbing Mao et al. Oncotarget. .

Abstract

Reactive oxide species are the middle products of normal metabolism, and play a crucial role in cell signaling transduction. On the contrary, accumulation of excess reactive oxide species results in oxidative stress that often brings multifarious impairment to cells, including decrease of ATP level in cells, elevation of cytosolic Ca2+, DNA damage, dysfunction of biological function in lipid bilayer and so on. These effects will finally lead to all kinds of diseases. Tea polyphenols are widely considered as a kind of excellent antioxidant agents. It can be antioxidants by directly scavenging reactive oxide species or chelating transition metals, and indirectly upregulating the activity of antioxidant enzymes. In addition, tea polyphenols have also been observed a potent pro-oxidant capacity, which directly leads to the generation of reactive oxide species, and indirectly induces apoptosis and death of cancer cells. The underlying characters of its pro-oxidant activity in some diseases is not well understood. The present review we will discuss the dual character of tea polyphenols, both antioxidant and pro-oxidant properties, in some human diseases induced by oxidative stress.

Keywords: antioxidant capacity; oxidative stress; pro-oxidant capacity; tea polyphenols.

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Conflict of interest statement

CONFLICTS OF INTEREST None.

Figures

Figure 1
Figure 1. The main phenolic compounds of tea polyphenols
Figure 2
Figure 2. The process of oxidative stress-induced diseases
Figure 3
Figure 3. Pathogenesis of oxidative stress-induced neurodegenerative diseases
Figure 4
Figure 4. Pathogenesis of oxidative stress-induced carcinogenesis
Figure 5
Figure 5. Pathogenesis of oxidative stress-induced inflammation
Figure 6
Figure 6. The mechanism of tea polyphenols curing diseases triggered by oxidative stress
Figure 7
Figure 7. Some special mechanisms that tea polyphenols inhibit cancers, except increasing antioxidant capacity
See this image and copyright information in PMC

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