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Case Reports
. 2017 Oct-Dec;12(4):727-730.
doi: 10.4103/ajns.AJNS_39_15.

Tumor Recurrence in a Glioblastoma Patient after Discontinuation of Prolonged Temozolomide Treatment

Wei-Lung Tseng  1 , Hsu-Hsien Hsu  1 , Yun Chen  2   3 , Sheng-Hong Tseng  1
Affiliations
Case Reports

Tumor Recurrence in a Glioblastoma Patient after Discontinuation of Prolonged Temozolomide Treatment

Wei-Lung Tseng et al. Asian J Neurosurg. 2017 Oct-Dec.

Abstract

There is no consensus regarding the duration of temozolomide (TMZ) treatment for glioblastoma multiforme (GBM). We report a 53-year-old woman who had a left frontal GBM. The tumor showed good response to TMZ treatment, which was discontinued after 5.5 years with recurrence of tumor at the posterior fossa 6 months later, although there was no definite tumor recurrence in the left frontal region. The tumor failed to respond to the reinstitution of TMZ therapy. Continuous TMZ treatment may be necessary in GBM patients on prolonged TMZ treatment despite improved neurological condition and imaging studies revealing marked tumor regression.

Keywords: Glioblastoma; temozolomide; tumor recurrence.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
The preoperative MRI of the brain. Preoperative MRI of the brain. (a) Unenhanced T1-weighted MRI, axial section. (b) T2-weighted MRI, axial section. (c) Gadolinium-enhanced T1-weighted MRI, axial section. (d) Gadolinium-enhanced T1-weighted MRI, coronal section. MRI – Magnetic resonance imaging
Figure 2
Figure 2
MRI of the brain from 1 week after surgery to 3 years and 4 months after diagnosis. Gadolinium-enhanced T1-weighted MRI. (a and b) 1 week after surgery ([a] axial section, [b] coronal section). (c and d) 2.5 months after diagnosis ([c] axial section, [d] coronal section). (e and f) Two years and 2 months after diagnosis ([e] axial section, [f] coronal section). (g and h) Three years and 4 months after diagnosis ([g] axial section, [h] coronal section). MRI – Magnetic resonance imaging
Figure 3
Figure 3
MRI of the brain from 5 years and 8 months to 6 years and 8 months after diagnosis. Gadolinium-enhanced T1-weighted MRI. (a-d) Five years and 8 months after diagnosis ([a and c] axial section, [b and d] coronal section). (e-h) Six years and 4 months after diagnosis ([e and g] axial section, [f and h] coronal section). (i-l) Six years and 8 months after diagnosis ([i and k] axial section, [j and l] coronal section). MRI – Magnetic resonance imaging
See this image and copyright information in PMC

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