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. 2017 Oct;45(5):260-263.
doi: 10.5152/TJAR.2017.04578. Epub 2017 Oct 1.

Effective Loading Dose of Dexmedetomidine to Induce Adequate Sedation in Parturients Undergoing Caesarean Section Under Spinal Anaesthesia

Jinguo Wang  1 , Zhanyang Han  2 , Honglan Zhou  1 , Na Wang  3 , Haichun Ma  3
Affiliations

Effective Loading Dose of Dexmedetomidine to Induce Adequate Sedation in Parturients Undergoing Caesarean Section Under Spinal Anaesthesia

Jinguo Wang et al. Turk J Anaesthesiol Reanim. 2017 Oct.

Abstract

Objective: To calculate the effective dose (ED) of dexmedetomidine for caesarean section under spinal anaesthesia.

Methods: Consecutive parturients scheduled for caesarean section under spinal anaesthesia were included. The loading dose of dexmedetomidine was evaluated using the up-and-down method, starting at 1.0 μg kg-1 and a step size of 0.1 μg kg-1. The loading dexmedetomidine was administrated by the venous route for 10 min, and afterwards a maintenance dose began at a rate of 0.3 μg kg-1 h-1 in all parturients. Adequate sedation was defined as a Ramsay sedation score ≥3. The ED50 and ED95 of loading dexmedetomidine were calculated using probit regression.

Results: The ED50 and ED95 of loading dexmedetomidine for adequate sedation were 0.82 μg kg-1 (95% confidence intervals [CI] 0.73-0.89 μg kg-1) and 0.96 μg kg-1 (95% CI 0.90-1.39 μg kg-1), respectively.

Conclusion: The ED50 and ED95 of loading dexmedetomidine to achieve adequate sedation were 0.82 μg kg-1 and 0.96 μg kg-1 for caesarean section under spinal anaesthesia.

Keywords: Dexmedetomidine; effective dose; sedation; spinal anaesthesia.

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Conflict of interest statement

Conflict of Interest: No conflict of interest was declared by the authors.

Figures

Figure 1
Figure 1
The sedation effect of different loading doses of dexmedetomidine in 25 consecutive parturients undergoing caesarean section under spinal anaesthesia
See this image and copyright information in PMC

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