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. 2017 Oct 27;5(1):e410.
doi: 10.1212/NXI.0000000000000410. eCollection 2018 Jan.

Brachio-cervical inflammatory myopathy with associated scleroderma phenotype and lupus serology

Andrew F Gao  1 , Philip A Saleh  1 , Charles D Kassardjian  1 , Ophir Vinik  1 , David G Munoz  1
Affiliations

Brachio-cervical inflammatory myopathy with associated scleroderma phenotype and lupus serology

Andrew F Gao et al. Neurol Neuroimmunol Neuroinflamm. .
No abstract available

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Figures

Figure
Figure. Muscle biopsy of the left biceps showing the characteristic pathologic findings in BCIM
(A.a, B) Cryostat sections stained with hematoxylin phloxine saffron show widespread muscle fiber atrophy without perifascicular distribution, endomysial fibrosis, and numerous necrotic and regenerating fibers. (A.b) Alkaline phosphatase staining of the perimysium. (C) Multiple inflammatory foci, with a perivascular and perimysial (D) and endomysial distribution (E). Germinal centers with polarization were occasionally seen (F), which stained for CD10 and bcl-6, but not bcl-2, ruling out follicular lymphoma (not shown). Immunohistochemistry showed that inflammatory infiltrates were composed of CD20+ B cells (G) along with CD4+ and CD8+ T cells (not shown). Multiple CD20+ B-cell foci were appreciated (H). Membrane attack complex (MAC) deposition was widespread in the endomysium, with several examples of MAC deposition around multiple fibers, confirming its endomysial location (I, green arrows).
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