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. 2017 Nov 7;10(1):577.
doi: 10.1186/s13104-017-2897-x.

Hyperuricemia in type 2 diabetic model KK-Ay/Ta mice: a potent animal model with positive correlation between insulin resistance and plasma high uric acid levels

Shin-Ichi Adachi  1 , Fumiaki Yoshizawa  1   2 , Kazumi Yagasaki  3
Affiliations

Hyperuricemia in type 2 diabetic model KK-Ay/Ta mice: a potent animal model with positive correlation between insulin resistance and plasma high uric acid levels

Shin-Ichi Adachi et al. BMC Res Notes. .

Abstract

Objective: Hyperuricemia is recognized as a main cause of gout. Accumulating clinical evidence suggests that hyperuricemia is strongly associated with insulin resistance and abnormal glucose metabolism. However, there seem no proper animal models for investigating such associations. Ideal animal model is considered to be hyperuricemic as well as diabetic. Selecting the KK-Ay/Ta mouse model, the relationship between hyperuricemia and insulin resistance has been studied to characterize such an animal model.

Results: Male type 2 diabetic KK-Ay/Ta and age-matched normal C57BL/6J mice were maintained on a basal 20% casein diet for 35 days. Food intake, body weight gain, levels of plasma uric acid, glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), and triglyceride in KK-Ay/Ta mice were significantly higher than those in normal mice. Plasma uric acid levels showed significant positive correlations with plasma glucose, insulin, HOMA-IR and triglyceride levels. These results suggest that the KK-Ay/Ta mouse strain is useful for studies on correlation between hyperuricemia and insulin resistance, and for those on effects of foods and their components on the relations.

Keywords: Hyperglycemia; Hyperuricemia; Insulin resistance; KK-Ay/Ta mouse.

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Figures

Fig. 1
Fig. 1
Changes of time-dependent fasting blood glucose (a), plasma glucose (b), insulin (c), HOMA-IR (d), uric acid (e), triglyceride (f), cholesterol (g) and hs-CRP (h) in normal C57BL/6J Jcl and diabetic KK-Ay/Ta Jcl mice. Each value represents the mean ± SEM of 6 mice. *Significantly different from corresponding normal values at P < 0.05
Fig. 2
Fig. 2
Correlations between plasma uric acid and other plasma parameters, glucose (a), insulin (b), HOMA-IR (c), triglyceride (d), cholesterol (e) and hs-CRP (f). Data were analyzed by Pearson correlation test in normal C57BL/6J and diabetic KK-Ay/Ta mice. Symbol: ○, Normal; ●, Diabetic
See this image and copyright information in PMC

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