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. 2018 Jun;36(3):370-379.
doi: 10.1007/s10637-017-0538-9. Epub 2017 Nov 8.

Cyclodextrin polymers as nanocarriers for sorafenib

Valentina Giglio  1 , Maurizio Viale  2 , Vittorio Bertone  3 , Irena Maric  2 , Rita Vaccarone  3 , Graziella Vecchio  4
Affiliations

Cyclodextrin polymers as nanocarriers for sorafenib

Valentina Giglio et al. Invest New Drugs. 2018 Jun.

Abstract

Polymeric nanoparticles based on cyclodextrins are currently undergoing clinical trials as new promising nanotherapeutics. In light of this interest, we investigated cyclodextrin cross-linked polymers with different lengths as carriers for the poorly water-soluble drug sorafenib. Both polymers significantly enhanced sorafenib solubility, with shorter polymers showing the most effective solubilizing effect. Inclusion complexes between sorafenib and the investigated polymers exhibited an antiproliferative effect in tumor cells similar to that of free sorafenib. Polymer/Sorafenib complexes also showed lower in vivo tissue toxicity than with free sorafenib in all organs. Our results suggest that the inclusion of sorafenib in polymers represents a successful strategy for a new formulation of this drug.

Keywords: Anticancer drug; Drug carriers; Nanoparticles; Solubility; Toxicity.

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