Review of antibiotic use in respiratory disorders at a regional hospital in Queensland

Abstract

tAdherence to antibiotic guidelines has been shown to improve outcomes in several clinical situations.Respiratory conditions are a major cause of mortality and morbidity in Queensland. A recent study showedlow levels of compliance with antibiotic guidelines in a Queensland metropolitan hospital. We undertookan audit of antibiotic use in a regional Queensland hospital against Therapeutic Guideline recommenda-tions. Therapeutic Guideline recommendations were followed in 16% of cases with ceftriaxone the mostcommonly prescribed. Re-admission rate within 28 days was for 53%, 26%, 11% and 5% respectively forceftriaxone, benzylpenicillin, amoxicillin/clavulanate and ceftriaxone combined doxycycline. Less thanhalf of patients treated for pneumonia had concordant radiographic changes. Admission via the emer-gency department may be a factor in the preference for intravenous injection of ceftriaxone and presenceof non-infective co-morbidities may also contribute to re-admissions. Considerable challenges exist inimproving compliance with antibiotic guidelines which can improve patient outcomes and antibioticstewardship.