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Comment
. 2017 Nov 7;26(5):697-698.
doi: 10.1016/j.cmet.2017.10.012.

What Ignites UCP1?

Barbara Cannon  1 , Jan Nedergaard  2
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Free article
Comment

What Ignites UCP1?

Barbara Cannon et al. Cell Metab. .
Free article

Abstract

We thought we knew how the heat-producing uncoupling protein 1 in brown adipose tissue was activated: by fatty acids released upon lipid droplet breakdown in the brown adipocytes. However, two studies in this issue (Schreiber et al., 2017; Shin et al., 2017) imply that this classical model may not be valid: heat can be produced in brown fat without intracellular lipolysis.

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