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Comment
. 2017 Nov 7;26(5):701-702.
doi: 10.1016/j.cmet.2017.10.011.

Glial Cell Evolution: The Origins of a Lipid Store

Klaus-Armin Nave  1 , Iva D Tzvetanova  2 , Stefanie Schirmeier  3
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Glial Cell Evolution: The Origins of a Lipid Store

Klaus-Armin Nave et al. Cell Metab. .
Free article

Abstract

In Drosophila, neuronal mitochondria that lack OXPHOS generate ROS-protective fatty acids and lipid droplets in associated glia. In this issue, Liu et al. (2017) demonstrate that neuronal lipid synthesis is driven by the glial lactate shuttle. This lipoprotein-dependent deposition of lipids may be at the origin of glial specializations evolving in vertebrates.

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