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. 2018 Feb;29(2):571-578.
doi: 10.1681/ASN.2017070819. Epub 2017 Nov 8.

Overweight and Obesity Are Predictors of Progression in Early Autosomal Dominant Polycystic Kidney Disease

Kristen L Nowak  1 , Zhiying You  2 , Berenice Gitomer  2 , Godela Brosnahan  2 , Vicente E Torres  3 , Arlene B Chapman  4 , Ronald D Perrone  5 , Theodore I Steinman  6 , Kaleab Z Abebe  7 , Frederic F Rahbari-Oskoui  8 , Alan S L Yu  9 , Peter C Harris  3 , Kyongtae T Bae  10 , Marie Hogan  3 , Dana Miskulin  5 , Michel Chonchol  2
Affiliations

Overweight and Obesity Are Predictors of Progression in Early Autosomal Dominant Polycystic Kidney Disease

Kristen L Nowak et al. J Am Soc Nephrol. 2018 Feb.

Abstract

The association of overweight/obesity with disease progression in patients with autosomal dominant polycystic kidney disease (ADPKD) remains untested. We hypothesized that overweight/obesity associates with faster progression in early-stage ADPKD. Overall, 441 nondiabetic participants with ADPKD and an eGFR>60 ml/min per 1.73 m2 who participated in the Halt Progression of Polycystic Kidney Disease Study A were categorized on the basis of body mass index (BMI; calculated using nonkidney and nonliver weight) as normal weight (18.5-24.9 kg/m2; reference; n=192), overweight (25.0-29.9 kg/m2; n=168), or obese (≥30 kg/m2; n=81). We evaluated the longitudinal (5-year) association of overweight/obesity with change in total kidney volume (TKV) by magnetic resonance imaging using linear regression and multinomial logistic regression models. Among participants, mean±SD age was 37±8 years, annual percent change in TKV was 7.4%±5.1%, and BMI was 26.3±4.9 kg/m2 The annual percent change in TKV increased with increasing BMI category (normal weight: 6.1%±4.7%, overweight: 7.9%±4.8%, obese: 9.4%±6.2%; P<0.001). In the fully adjusted model, higher BMI associated with greater annual percent change in TKV (β=0.79; 95% confidence interval [95% CI], 0.18 to 1.39, per 5-unit increase in BMI). Overweight and obesity associated with increased odds of annual percent change in TKV ≥7% compared with <5% (overweight: odds ratio, 2.02; 95% CI, 1.15 to 3.56; obese: odds ratio, 3.76; 95% CI, 1.81 to 7.80). Obesity also independently associated with greater eGFR decline (slope) versus normal weight (fully adjusted β =-0.08; 95% CI, -0.15 to -0.02). In conclusion, overweight and, particularly, obesity are strongly and independently associated with rate of progression in early-stage ADPKD.

Keywords: ADPKD; clinical epidemiology; obesity; renal function decline; total kidney volume.

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Figures

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Graphical abstract
Figure 1.
Figure 1.
Annual percent change in TKV is greater with increasing BMI category. Annual percent change in TKV according to classification as normal weight, overweight, and obese. *P<0.001.
See this image and copyright information in PMC

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