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. 2017 Nov 8;7(1):15039.
doi: 10.1038/s41598-017-15390-w.

Decreased absolute numbers of CD3+ T cells and CD8+ T cells during aging in herpes zoster patients

Li Wei  1 , Jianguang Zhao  2 , Wei Wu  1 , Yu Zhang  3 , Xuyan Fu  1 , Lifeng Chen  3 , Xiaoting Wang  4
Affiliations

Decreased absolute numbers of CD3+ T cells and CD8+ T cells during aging in herpes zoster patients

Li Wei et al. Sci Rep. .

Abstract

Herpes zoster (HZ) is an infectious dermatosis with high incidence worldwide. Age is a key risk factor for HZ, and postherpetic neuralgia (PHN) is the main sequelae. Until now, no index has been available to predict the pathogenesis of PHN, and rare reports have focused on the immune response during aging and PHN. In this study, we selected immunoglobulin and complement proteins as markers for humoral immunity, while T lymphocyte subsets and natural killer (NK) cells were selected as markers for cell immunity, to systematically study the characteristics of immune responses in the peripheral blood of HZ patients. Our data showed that the absolute number of CD3+ T cells and CD8+ T cells decreased during aging and PHN. This implies that more attention should be paid to prevent the occurrence of PHN, especially in the aged population.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Gating strategy of T lymphocyte subsets and NK cells.
Figure 2
Figure 2
Gating strategy of different phenotypes of CD8 T cells.
Figure 3
Figure 3
Absolute numbers of T lymphocyte subsets and NK cells in different age groups with herpes zoster.
Figure 4
Figure 4
Absolute numbers of T lymphocyte subsets and NK cells of PHN patients and non-PHN patients in three age groups.
Figure 5
Figure 5
Absolute numbers of different phenotypes of CD8 T cells in PHN patients and non-PHN patients for old age HZ patients and controls.
See this image and copyright information in PMC

References

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