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. 2017 Oct-Dec;9(4):149-153.
doi: 10.4103/ijt.ijt_32_17.

Insignificant Correlation between Thyroid Hormone and Antithyroid Peroxidase Antibodies in Alopecia Areata Patients in Northern Rajasthan

Gagandeep Kaur  1 , C M Kuldeep  1 , Puneet Bhargava  1 , Deepak Kumar Mathur  1 , Sonam Sharda  1 , Pulkit Chaturvedi  1
Affiliations

Insignificant Correlation between Thyroid Hormone and Antithyroid Peroxidase Antibodies in Alopecia Areata Patients in Northern Rajasthan

Gagandeep Kaur et al. Int J Trichology. 2017 Oct-Dec.

Abstract

Background: Alopecia areata (AA) is a common, recurrent form of nonscarring alopecia which often presents as circumscribed patches of spontaneous hair loss. The global prevalence of this disease varies from 0.1% to 0.2% in general population and 7-30 cases per 1000 dermatological patients. The etiology of AA still remains uncertain; however, genetic or environmental factor and autoimmunity are claimed responsible for it. Various autoimmune diseases, such as Hashimoto's thyroiditis, diabetes mellitus, vitiligo, and lupus erythematosus, have been reported in association with AA.

Aim: The index study was aimed at estimation of serum T3, T4, thyroid-stimulating hormone, and antithyroid peroxidase (TPO) antibodies.

Material and methods: Similar age/sex-matched AA patients and controls (110 in each group). Enhanced chemiluminescence immunoassay for thyroid profile and anti-TPO antibody level estimation in veinous blood sample.

Observations: The mean/standard deviation (SD) of T3 was 3.30 ± 0.84 pg/ml in AA while 3.27 ± 0.67 pg/ml in controls (P = 0.302). Serum mean/SD of T4 level was1.23 ± 0.76 ng/dl in AA patients while 1.17 ± 0.34 ng/dl in controls (P = 0.522). The mean/SD of anti-TPO levels in AA patients was 21.52 ± 35.09 while 56.43 ± 140.72 in controls (P = 0.136).

Limitation: The limitation of this study was moderate number of AA patients and different genotype of study population.

Conclusion: Occurrence of thyroid dysfunction and evidence of anti-TPO antibodies in AA is rare event in this study population.

Keywords: Alopecia areata; thyroid hormone; thyroperoxidase antibody.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Patchy Alopecia over beard region
Figure 2
Figure 2
Alopecia totalis
Figure 3
Figure 3
Sisaipho
Figure 4
Figure 4
Ophiasis
Figure 5
Figure 5
Insignificant difference in T3 level in alopecia areata patients and controls (P = 0.302)
Figure 6
Figure 6
Serum T4 level in alopecia areata patients and controls (P = 0.522)
Figure 7
Figure 7
Distribution of antithyroid peroxidase antibody levels in alopecia areata cases and controls (P = 0.139 NS)
See this image and copyright information in PMC

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