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Review
. 2017 Oct 1;7(10):1990-1995.
eCollection 2017.

Elucidating immunometabolic targets in glioblastoma

Pooja Agarwal  1 , Michael J Pajor  1 , David M Anson  1 , Maheedhara R Guda  1 , Collin M Labak  1 , Andrew J Tsung  1   2   3 , Kiran K Velpula  1   2
Affiliations
Review

Elucidating immunometabolic targets in glioblastoma

Pooja Agarwal et al. Am J Cancer Res. .

Abstract

Immunometabolism has recently emerged on the forefront of cancer research as a new avenue to potentially develop more effective and targeted treatment options. Several pathologically altered metabolic targets across various cancer types have been identified, including lactate in aerobic glycolysis; tryptophan in amino acid metabolism; and arginine in the urea cycle. Numerous advancements have improved our understanding of the dual function of these targets in influencing immune functions as an auxiliary function to their well-established metabolic role. This paper provides a comprehensive overview of immunometabolism research and attempts to provide insight into potential immunometabolic targets in glioblastoma for the purpose of future development and study of targeted therapies.

Keywords: Arg1; IDO; Immunometabolism; LDHA; TDO; arginine; glioblastoma; iNOS; lactate; lactic acid; tryptophan.

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