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. 2018:1693:285-300.
doi: 10.1007/978-1-4939-7395-8_21.

Synthetic Biology to Engineer Bacteriophage Genomes

Ana Rita Costa  1 , Catarina Milho  1 , Joana Azeredo  1 , Diana Priscila Pires  2
Affiliations

Synthetic Biology to Engineer Bacteriophage Genomes

Ana Rita Costa et al. Methods Mol Biol. 2018.

Abstract

Recent advances in the synthetic biology field have enabled the development of new molecular biology techniques used to build specialized bacteriophages with new functionalities. Bacteriophages have been engineered towards a wide range of applications including pathogen control and detection, targeted drug delivery, or even assembly of new materials.In this chapter, two strategies that have been successfully used to genetically engineer bacteriophage genomes are addressed: a yeast-based platform and bacteriophage recombineering of electroporated DNA.

Keywords: BRED; Bacteriophage; Bacteriophage engineering; YAC.

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