Polyglutamine inclusion body toxicity
- PMID: 29119663
- PMCID: PMC5744902
- DOI: 10.1002/mds.27226
Polyglutamine inclusion body toxicity
Comment on
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In Situ Architecture and Cellular Interactions of PolyQ Inclusions.Cell. 2017 Sep 21;171(1):179-187.e10. doi: 10.1016/j.cell.2017.08.009. Epub 2017 Sep 7. Cell. 2017. PMID: 28890085
References
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- Arrasate M, Mitra S, Schweitzer ES, Segal MR, Finkbeiner S. Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death. Nature. 2004;431:805–810. - PubMed
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- Kuemmerle S, Gutekunst CA, Klein AM, et al. Huntington aggregates may not predict neuronal death in Huntington’s disease. Ann Neurol. 1999;46:842–849. - PubMed
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- Bäuerlein FJB, Saha I, Mishra A, et al. In Situ Architecture and Cellular Interactions of PolyQ Inclusions. Cell. 2017;171:179–187. - PubMed
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- Tallaksen-Greene SJ, Ordway JM, et al. Hprt(CAG)146 mice: age of onset of behavioral abnormalities, time course of neuronal intranuclear inclusion accumulation, neurotransmitter marker alterations, mitochondrial function markers, and susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. J Comp Neurol. 2003;465:205–219. - PubMed
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