Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Jan;67(S145):13-15.
doi: 10.1111/aogs.1988.67.s145.13.

PROPHYLACTIC USE OF 15(S)15 METHYL PGF2α BY INTRAMUSCULAR ROUTE FOR CONTROL OF POSTPARTUM BLEEDING - A COMPARATIVE TRIAL WITH METHYLERGOMETRINE

P Bhattacharya, Devi Pk, S Jain, Kanthamani Cr, Raghavan Ks

PROPHYLACTIC USE OF 15(S)15 METHYL PGF2α BY INTRAMUSCULAR ROUTE FOR CONTROL OF POSTPARTUM BLEEDING - A COMPARATIVE TRIAL WITH METHYLERGOMETRINE

P Bhattacharya et al. Acta Obstet Gynecol Scand. 1988 Jan.

Abstract

In a multicentre trial (3 centres) the safety and efficacy of an intramuscular injection of 125 µg of 15(S)15 methyl PGF2α (Prostin 15M, Upjohn) was compared with methylergometrine for prophylactic control of bleeding during the third stage of labour. Three hundred patients were recruited for the study - 150 to each treatment group. The duration of the third stage was shorter in the patients (4.4 minutes) treated with Prostin 15M compared to the methylergometrine group (8.6 minutes). Similarly the blood loss during the third stage was reduced by 50% of that observed in the methylergometrine group (72 ml vs 145 ml). Prostin 15M, when used prophylactically was better than methylergometrine in controlling the blood loss during the third stage of labour.

PubMed Disclaimer

LinkOut - more resources