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Review
. 2017 Nov 9;9(11):1223.
doi: 10.3390/nu9111223.

Coffee Decreases the Risk of Endometrial Cancer: A Dose-Response Meta-Analysis of Prospective Cohort Studies

Alessandra Lafranconi  1   2 , Agnieszka Micek  3 , Fabio Galvano  4 , Sabrina Rossetti  5 , Lino Del Pup  6 , Massimiliano Berretta  7 , Gaetano Facchini  8
Affiliations
Review

Coffee Decreases the Risk of Endometrial Cancer: A Dose-Response Meta-Analysis of Prospective Cohort Studies

Alessandra Lafranconi et al. Nutrients. .

Abstract

Aim: The aim of this study was to perform a comprehensive meta-analysis of the association between coffee consumption and risk of endometrial cancer.

Methods: Eligible studies were identified by searching the PubMed and EMBASE databases. The dose-response relationship as well as the risk of endometrial cancer for the highest versus the lowest categories of coffee consumption were assessed. Subgroup analyses considering the menopausal and receptor statuses, the smoking status, and the BMI (Body Mass Index) were performed in order to identify potential confounders.

Results: We identified a total of 12 studies eligible for meta-analysis. A dose-response meta-analysis showed a decreased risk of endometrial cancer. Moreover, a subgroup analysis indicated that coffee consumption is significantly associated with a decreased risk of postmenopausal cancer. Increasing coffee consumption by four cups per day was associated with a 20% reduction in endometrial cancer risk (relative risk (RR) 0.80; 95% confidence interval (CI) 0.72 to 0.89) and with a 24% reduction in postmenopausal cancer risk (RR 0.76; 95% CI 0.69 to 0.83).

Conclusions: Our findings suggest that increased coffee consumption is associated with decreased risk of endometrial cancer, and this association is observed also for postmenopausal cancer.

Keywords: caffeine; coffee; endometrial cancer; meta-analysis; postmenopausal; prospective cohort.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Selection process of relevant studies reporting on the association between coffee consumption and endometrial cancer risk.
Figure 2
Figure 2
Forest plot of summary relative risks (RRs) of endometrial cancer for the highest versus the lowest (reference) category of coffee consumption. Exposure categories are reported as identified in the original studies; in the dose–response analysis they were harmonized (range: 0–9 cups).
Figure 3
Figure 3
Dose–response association between coffee consumption and endometrial cancer risk (a) non-linear, total analysis; (b) linear, total analysis (c) non-linear, postmenopausal; (d) linear, postmenopausal.
See this image and copyright information in PMC

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