Sequestering Damage-associated Molecular Patterns in Critical Illness. A Novel Homeostatic Role for the Erythrocyte

doi:10.1164/rccm.201710-2094ED

Editorial

. 2018 Feb 15;197(4):416-418.

doi: 10.1164/rccm.201710-2094ED.

Sequestering Damage-associated Molecular Patterns in Critical Illness. A Novel Homeostatic Role for the Erythrocyte

Joseph A Hippensteel¹, Eric P Schmidt¹

Affiliations

PMID: 29120664
PMCID: PMC5955050
DOI: 10.1164/rccm.201710-2094ED

Editorial

Sequestering Damage-associated Molecular Patterns in Critical Illness. A Novel Homeostatic Role for the Erythrocyte

Joseph A Hippensteel et al. Am J Respir Crit Care Med. 2018.

. 2018 Feb 15;197(4):416-418.

doi: 10.1164/rccm.201710-2094ED.

Authors

Joseph A Hippensteel¹, Eric P Schmidt¹

Affiliation

¹ 1 Department of Medicine University of Colorado Denver Aurora, Colorado.

PMID: 29120664
PMCID: PMC5955050
DOI: 10.1164/rccm.201710-2094ED

No abstract available

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Red Blood Cells Homeostatically Bind Mitochondrial DNA through TLR9 to Maintain Quiescence and to Prevent Lung Injury.
Hotz MJ, Qing D, Shashaty MGS, Zhang P, Faust H, Sondheimer N, Rivella S, Worthen GS, Mangalmurti NS. Hotz MJ, et al. Am J Respir Crit Care Med. 2018 Feb 15;197(4):470-480. doi: 10.1164/rccm.201706-1161OC. Am J Respir Crit Care Med. 2018. PMID: 29053005 Free PMC article.

Cited by

Update in Critical Care and Acute Respiratory Distress Syndrome 2018.
Douglas IS, Bednash JS, Fein DG, Mallampalli RK, Mansoori JN, Gershengorn HB. Douglas IS, et al. Am J Respir Crit Care Med. 2019 Jun 1;199(11):1335-1343. doi: 10.1164/rccm.201903-0550UP. Am J Respir Crit Care Med. 2019. PMID: 30958975 Free PMC article. No abstract available.

References

1. Boyapati RK, Tamborska A, Dorward DA, Ho GT. Advances in the understanding of mitochondrial DNA as a pathogenic factor in inflammatory diseases. 2017;6:169. - PMC - PubMed
1. Simmons JD, Lee YL, Mulekar S, Kuck JL, Brevard SB, Gonzalez RP, et al. Elevated levels of plasma mitochondrial DNA DAMPs are linked to clinical outcome in severely injured human subjects. 2013;258:591–596, discussion 596–598. - PMC - PubMed
1. Yamanouchi S, Kudo D, Yamada M, Miyagawa N, Furukawa H, Kushimoto S. Plasma mitochondrial DNA levels in patients with trauma and severe sepsis: time course and the association with clinical status. 2013;28:1027–1031. - PubMed
1. McGill MR, Staggs VS, Sharpe MR, Lee WM, Jaeschke H Acute Liver Failure Study Group. Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome. 2014;60:1336–1345. - PMC - PubMed
1. Nakahira K, Kyung SY, Rogers AJ, Gazourian L, Youn S, Massaro AF, et al. Circulating mitochondrial DNA in patients in the ICU as a marker of mortality: derivation and validation. 2013;10:e1001577–discussion e1001577. - PMC - PubMed

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[1] Boyapati RK, Tamborska A, Dorward DA, Ho GT. Advances in the understanding of mitochondrial DNA as a pathogenic factor in inflammatory diseases. 2017;6:169. - PMC - PubMed

[2] Boyapati RK, Tamborska A, Dorward DA, Ho GT. Advances in the understanding of mitochondrial DNA as a pathogenic factor in inflammatory diseases. 2017;6:169. - PMC - PubMed

[3] Simmons JD, Lee YL, Mulekar S, Kuck JL, Brevard SB, Gonzalez RP, et al. Elevated levels of plasma mitochondrial DNA DAMPs are linked to clinical outcome in severely injured human subjects. 2013;258:591–596, discussion 596–598. - PMC - PubMed

[4] Simmons JD, Lee YL, Mulekar S, Kuck JL, Brevard SB, Gonzalez RP, et al. Elevated levels of plasma mitochondrial DNA DAMPs are linked to clinical outcome in severely injured human subjects. 2013;258:591–596, discussion 596–598. - PMC - PubMed

[5] Yamanouchi S, Kudo D, Yamada M, Miyagawa N, Furukawa H, Kushimoto S. Plasma mitochondrial DNA levels in patients with trauma and severe sepsis: time course and the association with clinical status. 2013;28:1027–1031. - PubMed

[6] Yamanouchi S, Kudo D, Yamada M, Miyagawa N, Furukawa H, Kushimoto S. Plasma mitochondrial DNA levels in patients with trauma and severe sepsis: time course and the association with clinical status. 2013;28:1027–1031. - PubMed

[7] McGill MR, Staggs VS, Sharpe MR, Lee WM, Jaeschke H Acute Liver Failure Study Group. Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome. 2014;60:1336–1345. - PMC - PubMed

[8] McGill MR, Staggs VS, Sharpe MR, Lee WM, Jaeschke H Acute Liver Failure Study Group. Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome. 2014;60:1336–1345. - PMC - PubMed

[9] Nakahira K, Kyung SY, Rogers AJ, Gazourian L, Youn S, Massaro AF, et al. Circulating mitochondrial DNA in patients in the ICU as a marker of mortality: derivation and validation. 2013;10:e1001577–discussion e1001577. - PMC - PubMed

[10] Nakahira K, Kyung SY, Rogers AJ, Gazourian L, Youn S, Massaro AF, et al. Circulating mitochondrial DNA in patients in the ICU as a marker of mortality: derivation and validation. 2013;10:e1001577–discussion e1001577. - PMC - PubMed

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Sequestering Damage-associated Molecular Patterns in Critical Illness. A Novel Homeostatic Role for the Erythrocyte

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Sequestering Damage-associated Molecular Patterns in Critical Illness. A Novel Homeostatic Role for the Erythrocyte

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