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Comment
. 2017 Nov 8;22(5):575-576.
doi: 10.1016/j.chom.2017.10.012.

Mind Your Cs and Gs

Oliver I Fregoso  1
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Free article
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Mind Your Cs and Gs

Oliver I Fregoso. Cell Host Microbe. .
Free article

Abstract

How can an innate immune sensor shape viral evolution? In recent work, Takata et al. (2017) determined that the antiviral protein ZAP recognizes CG dinucleotide composition to differentiate self from non-self. This pressure may have driven CG dinucleotide suppression in HIV-1 and other RNA viruses to evade host antiviral defenses.

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