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Comment
. 2017 Nov 8;22(5):586-588.
doi: 10.1016/j.chom.2017.10.017.

Getting Your Head around Cerebral Malaria

Jeffrey D Dvorin  1
Affiliations
Comment

Getting Your Head around Cerebral Malaria

Jeffrey D Dvorin. Cell Host Microbe. .

Abstract

Cerebral malaria is one of the most severe complications of human infection by the Plasmodium falciparum parasite. In this issue of Cell Host & Microbe, Kessler et al. (2017) provide valuable insights into the diagnosis and pathogenesis of this poorly understood manifestation of malaria.

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Figures

Figure 1.
Figure 1.. Pathogenesis of Cerebral Malaria and Possible Interventions to Reduce Mortality
The pathogenesis of cerebral malaria involves both parasite and host factors. Parasite sequestration plays a central role in this pathogenesis. Possible interventions are indicated in green.
See this image and copyright information in PMC

Comment on

  • Linking EPCR-Binding PfEMP1 to Brain Swelling in Pediatric Cerebral Malaria.
    Kessler A, Dankwa S, Bernabeu M, Harawa V, Danziger SA, Duffy F, Kampondeni SD, Potchen MJ, Dambrauskas N, Vigdorovich V, Oliver BG, Hochman SE, Mowrey WB, MacCormick IJC, Mandala WL, Rogerson SJ, Sather DN, Aitchison JD, Taylor TE, Seydel KB, Smith JD, Kim K. Kessler A, et al. Cell Host Microbe. 2017 Nov 8;22(5):601-614.e5. doi: 10.1016/j.chom.2017.09.009. Epub 2017 Oct 26. Cell Host Microbe. 2017. PMID: 29107642 Free PMC article.

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