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Review
. 2017 Nov;3(11):744-748.
doi: 10.1016/j.trecan.2017.09.003. Epub 2017 Oct 4.

Basal S-Nitrosylation Is the Guardian of Tissue Homeostasis

Saori Furuta  1
Affiliations
Review

Basal S-Nitrosylation Is the Guardian of Tissue Homeostasis

Saori Furuta. Trends Cancer. 2017 Nov.

Abstract

Recent studies have uncovered that nitric oxide (NO) signaling is largely conducted by S-nitrosylation, involving >3000 proteins. The nitrosyl group could then travel further by transnitrosylation or be secreted, enabling regulation of the whole tissue. A subset of proteins are constitutively S-nitrosylated, playing roles in the regulation of tissue homeostasis.

Keywords: S-nitrosylation; homeostasis; nitric oxide; transnitrosylation.

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