Endothelial factors in the pathogenesis and treatment of chronic kidney disease Part I: General mechanisms: a joint consensus statement from the European Society of Hypertension Working Group on Endothelin and Endothelial Factors and The Japanese Society of Hypertension
- PMID: 29120962
- DOI: 10.1097/HJH.0000000000001599
Endothelial factors in the pathogenesis and treatment of chronic kidney disease Part I: General mechanisms: a joint consensus statement from the European Society of Hypertension Working Group on Endothelin and Endothelial Factors and The Japanese Society of Hypertension
Abstract
: Kidney damage is a common consequence of arterial hypertension, but is also a cause of atherogenesis. Dysfunction and/or harm of the endothelium in glomeruli and tubular interstitium damage the function of these structures and translates into dynamic changes of filtration fraction, with progressive reduction in glomerular filtration rate, expansion of extracellular fluid volume, abnormal ion balance, and hypoxia, ultimately leading to chronic kidney disease. Considering the key role played by endothelial dysfunction in chronic kidney disease, the Working Group on Endothelin and Endothelial Factors of the European Society of Hypertension and the Japanese Society of Hypertension have critically reviewed available knowledge on the mechanisms underlying endothelial cell injury. This resulted into two articles: in the first, we herein examine the mechanisms by which endothelial factors induce vascular remodeling and the role of different players, including endothelin-1, the renin-angiotensin-aldosterone system and their interactions, and of oxidative stress; in the second, we discuss the role of endothelial dysfunction in the major disease conditions that affect the kidney.
Similar articles
-
Endothelial factors in the pathogenesis and treatment of chronic kidney disease Part II: Role in disease conditions: a joint consensus statement from the European Society of Hypertension Working Group on Endothelin and Endothelial Factors and the Japanese Society of Hypertension.J Hypertens. 2018 Mar;36(3):462-471. doi: 10.1097/HJH.0000000000001600. J Hypertens. 2018. PMID: 29135628 Review.
-
Activation of ATP-sensitive potassium channels protects vascular endothelial cells from hypertension and renal injury induced by hyperuricemia.J Hypertens. 2008 Dec;26(12):2326-38. doi: 10.1097/HJH.0b013e328312c8c1. J Hypertens. 2008. PMID: 19008712
-
The eNOS-NO pathway attenuates kidney dysfunction via suppression of inflammasome activation in aldosterone-induced renal injury model mice.PLoS One. 2018 Oct 3;13(10):e0203823. doi: 10.1371/journal.pone.0203823. eCollection 2018. PLoS One. 2018. PMID: 30281670 Free PMC article.
-
Elevated Endothelial Hypoxia-Inducible Factor-1α Contributes to Glomerular Injury and Promotes Hypertensive Chronic Kidney Disease.Hypertension. 2015 Jul;66(1):75-84. doi: 10.1161/HYPERTENSIONAHA.115.05578. Epub 2015 May 18. Hypertension. 2015. PMID: 25987665 Free PMC article.
-
Hypertension and chronic kidney disease.Indian Heart J. 2010 Sep-Oct;62(5):410-5. Indian Heart J. 2010. PMID: 23189882 Review. No abstract available.
Cited by
-
Mechanism of herbal medicine on hypertensive nephropathy (Review).Mol Med Rep. 2021 Apr;23(4):234. doi: 10.3892/mmr.2021.11873. Epub 2021 Feb 4. Mol Med Rep. 2021. PMID: 33537809 Free PMC article. Review.
-
Endothelial Glycocalyx as a Regulator of Fibrotic Processes.Int J Mol Sci. 2021 Mar 15;22(6):2996. doi: 10.3390/ijms22062996. Int J Mol Sci. 2021. PMID: 33804258 Free PMC article. Review.
-
Peptide 17 alleviates early hypertensive renal injury by regulating the Hippo/YAP signalling pathway.Nephrology (Carlton). 2022 Aug;27(8):712-723. doi: 10.1111/nep.14066. Epub 2022 Jul 5. Nephrology (Carlton). 2022. PMID: 35608936 Free PMC article.
-
Inhibition of Soluble Epoxide Hydrolase for Renal Health.Front Pharmacol. 2019 Jan 10;9:1551. doi: 10.3389/fphar.2018.01551. eCollection 2018. Front Pharmacol. 2019. PMID: 30687105 Free PMC article. Review.
-
Evaluation of Allostatic Load as a Mediator of Sleep and Kidney Outcomes in Black Americans.Kidney Int Rep. 2018 Dec 18;4(3):425-433. doi: 10.1016/j.ekir.2018.12.005. eCollection 2019 Mar. Kidney Int Rep. 2018. PMID: 30899870 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical