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. 2018 Jan 4;46(D1):D1083-D1090.
doi: 10.1093/nar/gkx1042.

Human Ageing Genomic Resources: new and updated databases

Robi Tacutu  1   2 , Daniel Thornton  1 , Emily Johnson  1 , Arie Budovsky  3   4 , Diogo Barardo  5   6 , Thomas Craig  1 , Eugene Diana  1 , Gilad Lehmann  3 , Dmitri Toren  3 , Jingwei Wang  1 , Vadim E Fraifeld  3 , João P de Magalhães  1
Affiliations

Human Ageing Genomic Resources: new and updated databases

Robi Tacutu et al. Nucleic Acids Res. .

Abstract

In spite of a growing body of research and data, human ageing remains a poorly understood process. Over 10 years ago we developed the Human Ageing Genomic Resources (HAGR), a collection of databases and tools for studying the biology and genetics of ageing. Here, we present HAGR's main functionalities, highlighting new additions and improvements. HAGR consists of six core databases: (i) the GenAge database of ageing-related genes, in turn composed of a dataset of >300 human ageing-related genes and a dataset with >2000 genes associated with ageing or longevity in model organisms; (ii) the AnAge database of animal ageing and longevity, featuring >4000 species; (iii) the GenDR database with >200 genes associated with the life-extending effects of dietary restriction; (iv) the LongevityMap database of human genetic association studies of longevity with >500 entries; (v) the DrugAge database with >400 ageing or longevity-associated drugs or compounds; (vi) the CellAge database with >200 genes associated with cell senescence. All our databases are manually curated by experts and regularly updated to ensure a high quality data. Cross-links across our databases and to external resources help researchers locate and integrate relevant information. HAGR is freely available online (http://genomics.senescence.info/).

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Figures

Figure 1.
Figure 1.
Patterns of ageing research for different human genes over time. The proportion of publications that focused mainly on ageing research are shown in red, the remaining publications are shown in blue.
Figure 2.
Figure 2.
(A) Combined HAGR and senescence.info unique visitors per month (black line). The secondary axis and grey bars show the yearly growth in HAGR citations *HAGR became publicly available online in mid-2004. **Data to end of August 2017. (B) Usage by percentage of the different HAGR databases in 2017.
See this image and copyright information in PMC

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