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Multicenter Study
. 2017 Dec 1:181:235-241.
doi: 10.1016/j.drugalcdep.2017.09.034. Epub 2017 Oct 28.

The impact of long-term moderate and heavy alcohol consumption on incident atherosclerosis among persons living with HIV

N E Kelso-Chichetto  1 , M Plankey  2 , D S Sheps  3 , A G Abraham  4 , X Chen  3 , S Shoptaw  5 , R C Kaplan  6 , W S Post  7 , R L Cook  3
Affiliations
Multicenter Study

The impact of long-term moderate and heavy alcohol consumption on incident atherosclerosis among persons living with HIV

N E Kelso-Chichetto et al. Drug Alcohol Depend. .

Abstract

Background: Level of alcohol consumption is associated with differential risk of atherosclerosis, but little research has investigated this association among HIV+ persons. We evaluated the association between long-term alcohol use and incident atherosclerosis among HIV+ persons.

Methods: We utilized data from HIV+ participants of the Women's Interagency HIV Study (n=483) and the Multicenter AIDS Cohort Study (n=305) without history of cardiovascular disease. Atherosclerosis was assessed two times by B-mode carotid artery ultrasound imaging from 2004 to 2013. Presence of plaque was defined as focal carotid intima-media thickness over 1.5mm. Those with no plaque at baseline and plaque at follow-up were considered incident cases of atherosclerosis. Group-based trajectory models were used to categorize participants into 10-year drinking patterns representing heavy, moderate, or abstinent-low. Multivariable logistic regressions were conducted to assess the association of long-term moderate and heavy use on atherosclerosis, compared to abstinent-low.

Results: Heavy alcohol consumption was not statistically significantly associated with risk for incident atherosclerosis in women (AOR 1.10, CI 0.40-3.02) or men (AOR 1.31, CI 0.43-4.00), compared to abstinence-low. Moderate consumption was associated with 54% lower odds for incident disease in men (AOR 0.46, CI 0.21-1.00), but not in women (AOR 1.08, CI 0.58-2.00). In cohort-combined analyses, alcohol consumption was not statistically significantly association with incident atherosclerosis (moderate AOR 0.78, CI 0.48-1.27; heavy AOR 1.33, CI 0.66-2.69).

Conclusion: Moderate alcohol consumption was associated with a significant protective effect on incident atherosclerosis in men only. No other levels of alcohol consumption significantly predicted atherosclerosis in men and women compared to abstinent-low.

Keywords: Alcohol; Atherosclerosis; Cardiovascular disease; Carotid artery; HIV; Longitudinal; Subclinical.

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Conflict of interest statement

Conflict of interest

The authors report no conflicts of interest.

Figures

Fig. 1
Fig. 1
10-year alcohol consumption trajectories by cohort. Panel A: Alcohol consumption patterns in women prior to incident atherosclerosis assessment; Panel B: Alcohol consumption patterns in men prior to incident atherosclerosis assessment
See this image and copyright information in PMC

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