Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2017 Nov 10;358(6364):716-718.
doi: 10.1126/science.aaq0770.

Cell cycle proteins moonlight in multiciliogenesis

Michelle Levine  1 , Andrew Holland  2
Affiliations
Comment

Cell cycle proteins moonlight in multiciliogenesis

Michelle Levine et al. Science. .
No abstract available

PubMed Disclaimer

Figures

Figure
Figure. Stepwise progression of centriole biogenesis in proliferating and multiciliated cells
Multiciliogenesis requires the cell cycle machinery. During amplification, deuterosomes are formed on the side of the daughter centrioles, producing multiple procentrioles. Once mature, centrioles detach, form distal appendages, and migrate to the apical plasma membrane, where they form basal bodies that nucleate cilia.
See this image and copyright information in PMC

Comment on

  • Calibrated mitotic oscillator drives motile ciliogenesis.
    Al Jord A, Shihavuddin A, Servignat d'Aout R, Faucourt M, Genovesio A, Karaiskou A, Sobczak-Thépot J, Spassky N, Meunier A. Al Jord A, et al. Science. 2017 Nov 10;358(6364):803-806. doi: 10.1126/science.aan8311. Epub 2017 Oct 5. Science. 2017. PMID: 28982797

References

    1. Spassky N, Meunier A. Nat Rev Mol Cell Biol. 2017;18:423. - PubMed
    1. Al Jord A, et al. Science. 2017;358:803. - PubMed
    1. Firat-Karalar EN, Stearns T. Philos Trans R Soc Lond B Biol Sci. 2014;369:20130460. - PMC - PubMed
    1. Levine MS, et al. Dev Cell. 2017;40:313. - PMC - PubMed
    1. Nigg EA, Raff JW. Cell. 2009;139:663. - PubMed

LinkOut - more resources