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. 1996 Sep 17;6(18):2151-2156.
doi: 10.1016/0960-894X(96)00366-6.

α-VINYLLYSINE AND α-VINYLARGININE ARE TIME-DEPENDENT INHIBITORS OF THEIR COGNATE DECARBOXYLASES

David B Berkowitz  1 , Wan-Jin Jahng  1 , Michelle L Pedersen  1
Affiliations

α-VINYLLYSINE AND α-VINYLARGININE ARE TIME-DEPENDENT INHIBITORS OF THEIR COGNATE DECARBOXYLASES

David B Berkowitz et al. Bioorg Med Chem Lett. .

Abstract

(±)-α-Vinyllysine and (±)-α-vinylarginine display time-dependent inhibition of L-lysine decarboxylase from B. cadaveris, and L-arginine decarboxylase from E. coli, respectively. A complete Kitz-Wilson analysis has been performed using a modification of the Palcic continuous UV assay for decarboxylase activity.

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