Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Oct 24:11:590.
doi: 10.3389/fnins.2017.00590. eCollection 2017.

The Role of SDF-1/CXCR4/CXCR7 in Neuronal Regeneration after Cerebral Ischemia

Xi Cheng  1 , Huibin Wang  1 , Xiuchun Zhang  1 , Shanshan Zhao  1 , Zhike Zhou  2 , Xiaopeng Mu  1 , Chuansheng Zhao  1 , Weiyu Teng  1
Affiliations
Review

The Role of SDF-1/CXCR4/CXCR7 in Neuronal Regeneration after Cerebral Ischemia

Xi Cheng et al. Front Neurosci. .

Abstract

Stromal cell-derived factor-1 is a chemoattractant produced by bone marrow stromal cell lines. It is recognized as a critical factor in the immune and central nervous systems (CNSs) as well as exerting a role in cancer. SDF-1 activates two G protein-coupled receptors, CXCR4 and CXCR7; these are expressed in both developing and mature CNSs and participate in multiple physiological and pathological events, e.g., inflammatory response, neurogenesis, angiogenesis, hematopoiesis, cancer metastasis, and HIV infection. After an ischemic stroke, SDF-1 levels robustly increase in the penumbra regions and participate in adult neural functional repair. Here we will review recent findings about SDF-1 and its receptor, analyse their functions in neurogeneration after brain ischemic injury: i.e., how the system promotes the proliferation, differentiation and migration of neural precursor cells and mediates axonal elongation and branching.

Keywords: CXCR4; CXCR7; ischemic stroke; neurogenesis; stromal cell-derived factor-1.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Overview of signaling pathways of the SDF-1/CXCR4/CXCR7 network. formula image,formula image, formula image,+P indicate processes involving in direct promoting effect, indirect promoting effect, inhibitory effect, and phosphorylation effect, respectively.
Figure 2
Figure 2
Schematic overview of SDF-1/CXCR4/CXCR7 interactions and their effects in neurogenesis.
Figure 3
Figure 3
Schematic overview of signaling pathways involved in the SDF-1/CXCR4/CXCR7 mediated axonal outgrowth, cells migration, and chemotaxis.
See this image and copyright information in PMC

References

    1. Arai K., Lo E. H. (2009). Oligovascular signaling in white matter stroke. Biol. Pharm. Bull. 32, 1639–1644. 10.1248/bpb.32.1639 - DOI - PMC - PubMed
    1. Arakawa Y., Bito H., Furuyashiki T., Tsuji T., Takemoto-Kimura S., Kimura K., et al. . (2003). Control of axon elongation via an SDF-1alpha/Rho/mDia pathway in cultured cerebellar granule neurons. J. Cell Biol. 161, 381–391. 10.1083/jcb.200210149 - DOI - PMC - PubMed
    1. Azim K., Raineteau O., Butt A. M. (2012). Intraventricular injection of FGF-2 promotes generation of oligodendrocyte-lineage cells in the postnatal and adult forebrain. Glia 60, 1977–1990. 10.1002/glia.22413 - DOI - PubMed
    1. Bajetto A., Barbero S., Bonavia R., Piccioli P., Pirani P., Florio T., et al. . (2001). Stromal cell-derived factor-1alpha induces astrocyte proliferation through the activation of extracellular signal-regulated kinases 1/2 pathway. J. Neurochem. 77, 1226–1236. 10.1046/j.1471-4159.2001.00350.x - DOI - PubMed
    1. Bakondi B. (2011). SDF-1a secreted by human CD133-derived multipotent stromal cells promotes neural progenitor cell survival through CXCR7. Stem Cells Dev. 20, 1021–1029. 10.1089/scd.2010.0198 - DOI - PMC - PubMed