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. 2017;12(3):186-191.
doi: 10.5114/pg.2017.70471. Epub 2017 Sep 30.

Blood serum levels of E-cadherin in patients with colorectal cancer

Dariusz Cepowicz  1 , Konrad Zaręba  1 , Anna Pryczynicz  2 , Tomasz Dawidziuk  1 , Joanna Żurawska  3 , Joanna Hołody-Zaręba  4 , Mariusz Gryko  1 , Bogusław Kędra  1
Affiliations

Blood serum levels of E-cadherin in patients with colorectal cancer

Dariusz Cepowicz et al. Prz Gastroenterol. 2017.

Abstract

Introduction: Colorectal cancer is the second most common cancer in terms of incidence in Poland. It is also the second most common cause of cancer deaths in men and the third women. In 75-80% of cases, depending on sources, it is of an occasional nature, and in the remaining 20-25% it has a hereditary character.

Aim: To compare the levels of E-cadherin in blood serum with some histopathological and clinical features. E-cadherin is an adhesion molecule, loss of function of which is suspected to influence both cancer progression and metastasis.

Material and methods: The study group comprised 48 patients diagnosed with colorectal cancer treated surgically in the Second Department of General and Gastroenterological Surgery, Medical University Hospital in Bialystok.

Results: As has been shown here, there is no statistically significant relationship between the levels of E-cadherin in blood serum and the possible prognosis to the progression of colorectal cancer. However, it was indicated that there appears to be a statistically significant relationship between blood serum E-cadherin levels and the levels of alanine aminotransferase and aspartate aminotransferase in patients with colorectal cancer.

Conclusions: The authors suggest that this significance may require further study.

Keywords: E-cadherin; alanine aminotransferase; aspartate aminotransferase; colon cancer; colorectal cancer.

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Figures

Figure 1
Figure 1
A graphic representation of E-cadherin levels in the serum of patients with colorectal cancer in comparison with control groups
Figure 2
Figure 2
The relationship between the level of E-cadherin and serum alanine aminotransferase (ALT) values
Figure 3
Figure 3
The relationship between the level of E-cadherin in the serum and the value of aspartate aminotransferase (AST)
See this image and copyright information in PMC

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