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Review
. 2017 Oct 19:6:1860.
doi: 10.12688/f1000research.11978.1. eCollection 2017.

Novel therapeutic approaches to simultaneously target rhinovirus infection and asthma/COPD pathogenesis

Carmen Mirabelli  1 , Els Scheers  1 , Johan Neyts  1
Affiliations
Review

Novel therapeutic approaches to simultaneously target rhinovirus infection and asthma/COPD pathogenesis

Carmen Mirabelli et al. F1000Res. .

Abstract

Rhinoviruses are exclusive respiratory pathogens and the etiological agents of the common cold. These viruses are increasingly reported to cause exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Here, we review the role of rhinovirus infections in the pathogenesis of asthma and COPD and we discuss the current and potential future treatments. We propose that, in order to prevent exacerbations, the design of novel therapeutics should focus on directly acting antivirals but also include the design of drugs that simultaneously inhibit viral replication and alleviate symptoms of asthma and COPD.

Keywords: COPD; antiviral; asthma; rhinovirus.

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Conflict of interest statement

Competing interests: The authors declare that they have no competing interests.No competing interests were disclosed.No competing interests were disclosed.

Figures

Figure 1.
Figure 1.. Rhinovirus inhibitors and asthma/COPD therapeutics.
( A) Schematic representation of the rhinovirus replication cycle, including different classes of inhibitors and representative examples thereof (italics). ( B) Cross-section of a bronchial tube with asthma/COPD pathogenesis and detail of the epithelial barrier illustrating the enhanced type 2 (Th2) immunologic response leading to airway remodeling. Relevant selections of therapeutics used for asthma/COPD treatment are indicated in italics. DC, dendritic cell; IFNγ, interferon gamma; IL, interleukin; LABA, long-acting B2-agonist bronchodilator; PDE4, phosphodiesterase 4; SABA, short-acting B2-agonist bronchodilator; ssRNA, single-stranded RNA; TGFβ, transforming growth factor-beta; UTR, untranslated region.
See this image and copyright information in PMC

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