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. 2017 Jun;4(2):116-123.
doi: 10.1007/s40472-017-0153-x. Epub 2017 May 24.

Concepts of Genomics in Kidney Transplantation

William S Oetting  1 , Casey Dorr  2   3 , Rory P Remmel  4 , Arthur J Matas  5 , Ajay K Israni  2   3 , Pamala A Jacobson  1
Affiliations

Concepts of Genomics in Kidney Transplantation

William S Oetting et al. Curr Transplant Rep. 2017 Jun.

Abstract

Purpose of review: Identification of genetic variants to aid in individualized treatment of solid organ allograft recipients would improve graft survival. We will review the current state of knowledge for associations of variants with transplant outcomes.

Recent findings: Many studies have yet to exhibit robust and reproducible results, however, pharmacogenomic studies focusing on cytochrome P450 (CYP) enzymes, transporters and HLA variants have shown strong associations with outcomes and have relevance towards drugs used in transplant. Genome wide association study data for the immunosuppressant tacrolimus have identified multiple variants in the CYP3A5 gene associated with trough concentrations. Additionally, APOL1 variants had been shown to confer risk to the development of end stage renal disease in African Americans.

Summary: The field is rapidly evolving and new technology such as next generation sequencing, along with larger cohorts, will soon be commonly applied in transplantation to understand genetic association with outcomes and personalized medicine.

Keywords: APOL1; Kidney transplant; genome wide association studies; genomics; pharmacogenomics; sequencing.

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References

    1. Sheldon S, Hasleton PS, Yonan NA, Rhaman AN, Deiraniya AK, Campbell CS, et al. Rejection in heart transplantation strongly correlates with HLA-DR antigen mismatch. Transplantation. 1994;58:719–22. - PubMed
    1. Zachary AA, Leffell MS. HLA Mismatching Strategies for Solid Organ Transplantation - A Balancing Act. Front Immunol. 2016;7:575. doi: 10.3389/fimmu.2016.00575. - DOI - PMC - PubMed
    1. Kruger B, Schroppel B. Genetic variations and transplant outcomes. Nephron Clin Pract. 2011;118:c49–54. doi: 10.1159/000320904. - DOI - PubMed
    1. Stojanova J, Pouche L, Picard N. Genetic polymorphisms in the immune response: A focus on kidney transplantation. Clin Biochem. 2016;49:363–76. doi: 10.1016/j.clinbiochem.2015.07.016. - DOI - PubMed
    1. Chand S, McKnight AJ, Borrows R. Genetic polymorphisms and kidney transplant outcomes. Curr Opin Nephrol Hypertens. 2014;23:605–10. doi: 10.1097/MNH.0000000000000068. - DOI - PubMed

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