Exclusive Enteral Nutrition Induces Remission in Pediatric Crohn's Disease via Modulation of the Gut Microbiota

doi:10.1155/2017/8102589

Review

. 2017:2017:8102589.

doi: 10.1155/2017/8102589. Epub 2017 Oct 16.

Exclusive Enteral Nutrition Induces Remission in Pediatric Crohn's Disease via Modulation of the Gut Microbiota

Dawei Gong¹, Xinjuan Yu¹, Lili Wang¹, Lingling Kong², Xiaojie Gong³, Quanjiang Dong¹

Affiliations

¹ Department of Central Laboratories and Gastroenterology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China.
² Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao 266071, China.
³ Department of Emergency Surgery, The Fifth People's Hospital of Jinan, Jinan 250022, China.

PMID: 29124070
PMCID: PMC5662815
DOI: 10.1155/2017/8102589

Review

Exclusive Enteral Nutrition Induces Remission in Pediatric Crohn's Disease via Modulation of the Gut Microbiota

Dawei Gong et al. Biomed Res Int. 2017.

. 2017:2017:8102589.

doi: 10.1155/2017/8102589. Epub 2017 Oct 16.

Authors

Dawei Gong¹, Xinjuan Yu¹, Lili Wang¹, Lingling Kong², Xiaojie Gong³, Quanjiang Dong¹

Affiliations

¹ Department of Central Laboratories and Gastroenterology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China.
² Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao 266071, China.
³ Department of Emergency Surgery, The Fifth People's Hospital of Jinan, Jinan 250022, China.

PMID: 29124070
PMCID: PMC5662815
DOI: 10.1155/2017/8102589

Abstract

Exclusive enteral nutrition (EEN) has been proven to be effective and safe in treating pediatric Crohn's disease (CD). EEN induces pediatric CD remission possibly through three pathways: (1) direct anti-inflammatory effects, (2) improved epithelial barrier function, and (3) modulation of the gut microbiota. Recent studies have demonstrated that modulation of the gut microbiota plays a major role in EEN-induced remission. Variations of microbial components, which directly influence the diversity and metabolic functions of the gut microbiota, are closely associated with the immunological conditions of the gut and the susceptibility to diseases. The reduction of proinflammatory microbial components and harmful microbial metabolites after EEN treatment greatly decreases the inflammatory injuries of the gut.

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References

1. Otley A. R., Russell R. K., Day A. S. Nutritional therapy for the treatment of pediatric Crohn's disease. Expert Review of Clinical Immunology. 2010;6(4):667–676. doi: 10.1586/eci.10.37. - DOI - PubMed
1. Borrelli O., Cordischi L., Cirulli M., et al. Polymeric diet alone versus corticosteroids in the treatment of active pediatric Crohn’s disease: a randomized controlled open-label trial. Clinical Gastroenterology and Hepatology. 2006;4(6):744–753. doi: 10.1016/j.cgh.2006.03.010. - DOI - PubMed
1. Levine A., Turner D., Gik T. P., et al. Comparison of outcomes parameters for induction of remission in new onset pediatric Crohn's disease: Evaluation of the porto IBD group “growth relapse and outcomes with therapy” (GROWTH CD) study. Inflammatory Bowel Diseases. 2014;20(2):278–285. doi: 10.1097/01.MIB.0000437735.11953.68. - DOI - PubMed
1. Grover Z., Muir R., Lewindon P. Exclusive enteral nutrition induces early clinical, mucosal and transmural remission in paediatric Crohn's disease. Journal of Gastroenterology. 2014;49(4):638–645. doi: 10.1007/s00535-013-0815-0. - DOI - PubMed
1. Ruemmele F. M., Veres G., Kolho K. L., et al. Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn's disease. Journal of Crohn's and Colitis. 2014;8(10):1179–1207. doi: 10.1016/j.crohns.2014.04.005. - DOI - PubMed

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[1] Otley A. R., Russell R. K., Day A. S. Nutritional therapy for the treatment of pediatric Crohn's disease. Expert Review of Clinical Immunology. 2010;6(4):667–676. doi: 10.1586/eci.10.37. - DOI - PubMed

[2] Otley A. R., Russell R. K., Day A. S. Nutritional therapy for the treatment of pediatric Crohn's disease. Expert Review of Clinical Immunology. 2010;6(4):667–676. doi: 10.1586/eci.10.37. - DOI - PubMed

[3] Borrelli O., Cordischi L., Cirulli M., et al. Polymeric diet alone versus corticosteroids in the treatment of active pediatric Crohn’s disease: a randomized controlled open-label trial. Clinical Gastroenterology and Hepatology. 2006;4(6):744–753. doi: 10.1016/j.cgh.2006.03.010. - DOI - PubMed

[4] Borrelli O., Cordischi L., Cirulli M., et al. Polymeric diet alone versus corticosteroids in the treatment of active pediatric Crohn’s disease: a randomized controlled open-label trial. Clinical Gastroenterology and Hepatology. 2006;4(6):744–753. doi: 10.1016/j.cgh.2006.03.010. - DOI - PubMed

[5] Levine A., Turner D., Gik T. P., et al. Comparison of outcomes parameters for induction of remission in new onset pediatric Crohn's disease: Evaluation of the porto IBD group “growth relapse and outcomes with therapy” (GROWTH CD) study. Inflammatory Bowel Diseases. 2014;20(2):278–285. doi: 10.1097/01.MIB.0000437735.11953.68. - DOI - PubMed

[6] Levine A., Turner D., Gik T. P., et al. Comparison of outcomes parameters for induction of remission in new onset pediatric Crohn's disease: Evaluation of the porto IBD group “growth relapse and outcomes with therapy” (GROWTH CD) study. Inflammatory Bowel Diseases. 2014;20(2):278–285. doi: 10.1097/01.MIB.0000437735.11953.68. - DOI - PubMed

[7] Grover Z., Muir R., Lewindon P. Exclusive enteral nutrition induces early clinical, mucosal and transmural remission in paediatric Crohn's disease. Journal of Gastroenterology. 2014;49(4):638–645. doi: 10.1007/s00535-013-0815-0. - DOI - PubMed

[8] Grover Z., Muir R., Lewindon P. Exclusive enteral nutrition induces early clinical, mucosal and transmural remission in paediatric Crohn's disease. Journal of Gastroenterology. 2014;49(4):638–645. doi: 10.1007/s00535-013-0815-0. - DOI - PubMed

[9] Ruemmele F. M., Veres G., Kolho K. L., et al. Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn's disease. Journal of Crohn's and Colitis. 2014;8(10):1179–1207. doi: 10.1016/j.crohns.2014.04.005. - DOI - PubMed

[10] Ruemmele F. M., Veres G., Kolho K. L., et al. Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn's disease. Journal of Crohn's and Colitis. 2014;8(10):1179–1207. doi: 10.1016/j.crohns.2014.04.005. - DOI - PubMed

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Exclusive Enteral Nutrition Induces Remission in Pediatric Crohn's Disease via Modulation of the Gut Microbiota

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Exclusive Enteral Nutrition Induces Remission in Pediatric Crohn's Disease via Modulation of the Gut Microbiota

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