Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Apr;26(4):1243-1252.
doi: 10.1007/s00520-017-3947-6. Epub 2017 Nov 9.

The effect of pre-transplant pain and chronic disease self-efficacy on quality of life domains in the year following hematopoietic stem cell transplantation

Madeline L O'Sullivan  1 , Rebecca A Shelby  1 , Caroline S Dorfman  1 , Sarah A Kelleher  1 , Hannah M Fisher  2 , Krista A Rowe Nichols  3 , Francis J Keefe  1 , Anthony D Sung  3 , Tamara J Somers  4
Affiliations

The effect of pre-transplant pain and chronic disease self-efficacy on quality of life domains in the year following hematopoietic stem cell transplantation

Madeline L O'Sullivan et al. Support Care Cancer. 2018 Apr.

Abstract

Purpose: Pain is common for hematopoietic stem cell transplant (HSCT) patients and may be experienced pre-transplant, acutely post-transplant, and for months or years following transplant. HSCT patients with persistent pain may be at risk for poor quality of life following transplant; however, the impact of pre-transplant pain on quality of life post-transplant is not well understood. Self-efficacy for chronic disease management is associated with quality of life among cancer patients and may impact quality of life for HSCT patients. The primary aim was to examine the effect of pre-transplant pain and self-efficacy on quality of life domains in the year following transplant.

Methods: One hundred sixty-six HSCT patients completed questionnaires providing information on pain, self-efficacy, and quality of life prior to transplant, at discharge, and 3-, 6-, and 12-months post-transplant as part of a longitudinal, observational study. Linear mixed modeling examined the trajectories of these variables and the effect of pre-transplant pain and self-efficacy on post-transplant quality of life.

Results: Pain and social and emotional quality of life remained stable in the year following transplant while self-efficacy and physical and functional quality of life improved. Pre-transplant pain was significantly related to lower physical well-being post-transplant. Lower pre-transplant self-efficacy was related to lower quality of life across all domains post-transplant.

Conclusion: Above and beyond the effect of pre-transplant pain, self-efficacy for managing chronic disease is important in understanding quality of life following transplant. Identifying patients with pain and/or low self-efficacy pre-transplant may allow for early intervention with self-management strategies.

Keywords: HSCT; Pain; Quality of life; Self-efficacy.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Figure 2
Figure 2
See this image and copyright information in PMC

References

    1. Bhatia S, Ramsay NKC, Robison LL, Snyder D, Stein A, Forman SJ, Weisdorf DJ, Francisco L, Carter A, Sun C-L, Baker KS, Gurney JG, McGlave PB, Nademanee A, O’Donnell M. Late mortality after allogeneic hematopoietic cell transplantation and functional status of long-term survivors: report from the Bone Marrow Transplant Survivor Study. Blood. 2007;110(10):3784–3792. doi: 10.1182/blood-2007-03-082933. - DOI - PMC - PubMed
    1. Cutler C. UpToDate. UpToDate; Waltham, MA: 2017. The approach to hematopoietic cell transplantation survivorship.
    1. Champlin R. Selection of Autologous or Allogeneic Transplantation. In: Kufe DW, Pollock RE, Weischselbaum RR, et al., editors. Cancer Medicine. 6th. BC Decker; Hamilton, ON: 2003.
    1. Mosher CE, Redd WH, Rini CM, Burkhalter JE, DuHamel KN. Physical, psychological, and social sequelae following hematopoietic stem cell transplantation: A review of the literature. Psycho-oncology. 2009;18(2):113–127. doi: 10.1002/pon.1399. - DOI - PMC - PubMed
    1. Niscola P, Romani C, Scaramucci L, Dentamaro T, Cupelli L, Tendas A, Piccioni D, Giovannini M, Tolu B, Cartoni C, Arcuri E, Perrotti A, Palumbo R, de Fabritiis P. Pain syndromes in the setting of haematopoietic stem cell transplantation for haematological malignancies. Bone Marrow Transplant. 2008;41(9):757–764. - PubMed

LinkOut - more resources