doi: 10.1016/s0006-291x(89)80219-0.
A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells
Affiliations
- PMID: 2912454
- DOI: 10.1016/s0006-291x(89)80219-0
Item in Clipboard
A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells
Biochem Biophys Res Commun.
.
Abstract
An enzyme in homogenates of porcine vascular endothelial cells forms L-citrulline from L-arginine. This enzyme is soluble and NADPH-dependent. In addition, the enzyme is inhibited by NG-monomethyl-L-arginine, suggesting that it is involved in the formation of nitric oxide by vascular endothelial cells.
Similar articles
-
Inhibition by methylene blue of the L-arginine metabolism to L-citrulline coupled with nitric oxide synthesis in cultured endothelial cells.Res Commun Chem Pathol Pharmacol. 1993 Oct;82(1):35-48. Res Commun Chem Pathol Pharmacol. 1993. PMID: 7505944
-
Stimulation by hydrogen peroxide of L-arginine metabolism to L-citrulline coupled with nitric oxide synthesis in cultured endothelial cells.Res Commun Chem Pathol Pharmacol. 1994 Jun;84(3):315-29. Res Commun Chem Pathol Pharmacol. 1994. PMID: 7938904
-
Endothelial cells metabolize NG-monomethyl-L-arginine to L-citrulline and subsequently to L-arginine.Biochem Biophys Res Commun. 1990 Mar 30;167(3):1037-43. doi: 10.1016/0006-291x(90)90627-y. Biochem Biophys Res Commun. 1990. PMID: 2322257
-
Enzymes of the L-arginine to nitric oxide pathway.J Nutr. 2004 Oct;134(10 Suppl):2748S-2751S; discussion 2765S-2767S. doi: 10.1093/jn/134.10.2748S. J Nutr. 2004. PMID: 15465779 Review.
-
The biological significance of nitric oxide formation from L-arginine.Biochem Soc Trans. 1989 Aug;17(4):642-4. doi: 10.1042/bst0170642. Biochem Soc Trans. 1989. PMID: 2670632 Review. No abstract available.
Cited by
-
Endothelial cell-specific loss of eNOS differentially affects endothelial function.PLoS One. 2022 Sep 23;17(9):e0274487. doi: 10.1371/journal.pone.0274487. eCollection 2022. PLoS One. 2022. PMID: 36149900 Free PMC article.
-
Characterization of the L-arginine:nitric oxide pathway in human platelets.Br J Pharmacol. 1990 Oct;101(2):325-8. doi: 10.1111/j.1476-5381.1990.tb12709.x. Br J Pharmacol. 1990. PMID: 1701676 Free PMC article.
-
Effects of interferon-gamma on nitric oxide synthase activity and endothelin-1 production by vascular endothelial cells.J Clin Invest. 1992 Sep;90(3):879-87. doi: 10.1172/JCI115963. J Clin Invest. 1992. PMID: 1381725 Free PMC article.
-
Antiviral effect of nitric oxide during Japanese encephalitis virus infection.Int J Exp Pathol. 2000 Apr;81(2):165-72. doi: 10.1046/j.1365-2613.2000.00148.x. Int J Exp Pathol. 2000. PMID: 10762444 Free PMC article.
-
The Application of Nitric Oxide for Ocular Hypertension Treatment.Molecules. 2021 Dec 1;26(23):7306. doi: 10.3390/molecules26237306. Molecules. 2021. PMID: 34885889 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
