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. 1989 Jan 16;158(1):348-52.
doi: 10.1016/s0006-291x(89)80219-0.

A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells

R M Palmer  1 , S Moncada
Affiliations

A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells

R M Palmer et al. Biochem Biophys Res Commun. .

Abstract

An enzyme in homogenates of porcine vascular endothelial cells forms L-citrulline from L-arginine. This enzyme is soluble and NADPH-dependent. In addition, the enzyme is inhibited by NG-monomethyl-L-arginine, suggesting that it is involved in the formation of nitric oxide by vascular endothelial cells.

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