Vitamin D Metabolism and the Implications for Atherosclerosis

Abstract

Vitamin D levels and metabolism may play a role in the pathogenesis and treatment of atherosclerosis and subsequent cardiovascular health. Herein, we discuss both normal and disordered vitamin D metabolism as it pertains to atherosclerosis, and we review major clinical trials regarding vitamin D levels and effects of supplementation. Although there are no official recommendations for vitamin D as it applies to atherosclerosis, it is clear that these two entities are linked. Further study of the complex association between vitamin D and atherosclerosis, as well as the effects of supplementation, are recommended.

Keywords: Atherosclerosis; Disclosures; Inflammation; No relevant disclosures; Vitamin D; Vitamin D deficiency.