Function of the myogenic regulatory factors Myf5, MyoD, Myogenin and MRF4 in skeletal muscle, satellite cells and regenerative myogenesis
- PMID: 29127046
- DOI: 10.1016/j.semcdb.2017.11.011
Function of the myogenic regulatory factors Myf5, MyoD, Myogenin and MRF4 in skeletal muscle, satellite cells and regenerative myogenesis
Abstract
Discovery of the myogenic regulatory factor family of transcription factors MYF5, MYOD, Myogenin and MRF4 was a seminal step in understanding specification of the skeletal muscle lineage and control of myogenic differentiation during development. These factors are also involved in specification of the muscle satellite cell lineage, which becomes the resident stem cell compartment inadult skeletal muscle. While MYF5, MYOD, Myogenin and MRF4 have subtle roles in mature muscle, they again play a crucial role in directing satellite cell function to regenerate skeletal muscle: linking the genetic control of developmental and regenerative myogenesis. Here, I review the role of the myogenic regulatory factors in developing and mature skeletal muscle, satellite cell specification and muscle regeneration.
Keywords: MRF4; Myf5; MyoD; Myogenin; Regeneration; Satellite cell; Skeletal muscle.
Copyright © 2017 Elsevier Ltd. All rights reserved.
Similar articles
-
Failure of Myf5 to support myogenic differentiation without myogenin, MyoD, and MRF4.Dev Biol. 2000 Mar 15;219(2):287-98. doi: 10.1006/dbio.2000.9621. Dev Biol. 2000. PMID: 10694423
-
Overlapping functions of the myogenic bHLH genes MRF4 and MyoD revealed in double mutant mice.Development. 1998 Jul;125(13):2349-58. doi: 10.1242/dev.125.13.2349. Development. 1998. PMID: 9609818
-
Myogenic waves and myogenic programs during Xenopus embryonic myogenesis.Dev Dyn. 2012 May;241(5):995-1007. doi: 10.1002/dvdy.23780. Dev Dyn. 2012. PMID: 22434732
-
The molecular regulation of muscle stem cell function.Cold Spring Harb Symp Quant Biol. 2008;73:323-31. doi: 10.1101/sqb.2008.73.064. Epub 2009 Mar 27. Cold Spring Harb Symp Quant Biol. 2008. PMID: 19329572 Review.
-
The myogenic regulatory factors, determinants of muscle development, cell identity and regeneration.Semin Cell Dev Biol. 2017 Dec;72:10-18. doi: 10.1016/j.semcdb.2017.11.010. Epub 2017 Nov 15. Semin Cell Dev Biol. 2017. PMID: 29127045 Free PMC article. Review.
Cited by
-
MicroRNA‑23a‑5p mediates the proliferation and differentiation of C2C12 myoblasts.Mol Med Rep. 2020 Nov;22(5):3705-3714. doi: 10.3892/mmr.2020.11475. Epub 2020 Sep 2. Mol Med Rep. 2020. PMID: 32901860 Free PMC article.
-
Comprehensive analysis of the expression patterns and function of the FTO-LINE1 axis in yak tissues and muscle satellite cells.Front Vet Sci. 2024 Sep 5;11:1448587. doi: 10.3389/fvets.2024.1448587. eCollection 2024. Front Vet Sci. 2024. PMID: 39301283 Free PMC article.
-
Identification and functional prediction of long non-coding RNAs related to skeletal muscle development in Duroc pigs.Anim Biosci. 2022 Oct;35(10):1512-1523. doi: 10.5713/ab.22.0020. Epub 2022 Apr 30. Anim Biosci. 2022. PMID: 35507853 Free PMC article.
-
Serum concentration impacts myosin heavy chain expression but not cellular respiration in human LHCN-M2 myoblasts undergoing differentiation.Exp Physiol. 2023 Feb;108(2):169-176. doi: 10.1113/EP090564. Epub 2023 Jan 9. Exp Physiol. 2023. PMID: 36621799 Free PMC article.
-
NRF2 and the Moirai: Life and Death Decisions on Cell Fates.Antioxid Redox Signal. 2023 Mar;38(7-9):684-708. doi: 10.1089/ars.2022.0200. Epub 2023 Feb 22. Antioxid Redox Signal. 2023. PMID: 36509429 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources