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Clinical Trial
. 2017 Nov 10;7(1):15329.
doi: 10.1038/s41598-017-15295-8.

Indoor PM2.5 exposure affects skin aging manifestation in a Chinese population

Anan Ding  1   2 , Yajun Yang  1   3 , Zhuohui Zhao  4 , Anke Hüls  5 , Andrea Vierkötter  5 , Ziyu Yuan  3 , Jing Cai  4 , Juan Zhang  3 , Wenshan Gao  2 , Jinxi Li  2 , Manfei Zhang  2 , Mary Matsui  6 , Jean Krutmann  5 , Haidong Kan  4 , Tamara Schikowski  7 , Li Jin  8   9   10 , Sijia Wang  11   12
Affiliations
Clinical Trial

Indoor PM2.5 exposure affects skin aging manifestation in a Chinese population

Anan Ding et al. Sci Rep. .

Abstract

Traffic-related air pollution is known to be associated with skin aging manifestations. We previously found that the use of fossil fuels was associated with skin aging, but no direct link between indoor air pollutants and skin aging manifestations has ever been shown. Here we directly measured the indoor PM2.5 exposure in 30 households in Taizhou, China. Based on the directly measured PM2.5 exposure and questionnaire data of indoor pollution sources, we built a regression model to predict the PM2.5 exposure in larger datasets including an initial examination group (N = 874) and a second examination group (N = 1003). We then estimated the association between the PM2.5 exposure and skin aging manifestations by linear regression. In the initial examination group, we showed that the indoor PM2.5 exposure levels were positively associated with skin aging manifestation, including score of pigment spots on forehead (12.5% more spots per increase of IQR, P-value 0.0371), and wrinkle on upper lip (7.7% more wrinkle on upper lip per increase of IQR, P-value 0.0218). The results were replicated in the second examination group as well as in the pooled dataset. Our study provided evidence that the indoor PM2.5 exposure is associated with skin aging manifestation in a Chinese population.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Description of skin aging signs in high indoor PM2.5 exposure group and low indoor PM2.5 exposure group in the directly measured samples. The study directly measured the indoor PM2.5 of 30 households, and divided them into high PM2.5 exposure group (N = 15, annual mean exposure >90 µg/m3) and low PM2.5 exposure group (N = 15, annual mean exposure ≤90 µg/m3). The wrinkles, laxity and size of pigment spots are normally distributed, and therefore arithmetic means (AM) is given; while number of pigment spots is log-normally distributed, and therefore geometric means (GM) is given. 95% CI is presented. Further skin aging manifestations are presented as occurrence respectively.
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References

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