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Randomized Controlled Trial
. 2017 Nov 10;7(1):15244.
doi: 10.1038/s41598-017-15456-9.

The positive effects of Xueshuan Xinmai tablets on brain functional connectivity in acute ischemic stroke: a placebo controlled randomized trial

Dongfeng Wei  1   2 , Daojun Xie  3 , He Li  1   2 , Yaojing Chen  4   2 , Di Qi  4   2 , Yujiao Wang  5 , Yangjun Zhang  4   2 , Kewei Chen  2   6 , Chuanfu Li  7 , Zhanjun Zhang  8   9
Affiliations
Randomized Controlled Trial

The positive effects of Xueshuan Xinmai tablets on brain functional connectivity in acute ischemic stroke: a placebo controlled randomized trial

Dongfeng Wei et al. Sci Rep. .

Abstract

Through a placebo controlled randomized study, the purpose of this report was to investigate the effects of Xueshuan Xinmai tablets (XXMT) on neurologic deficits, quality of life and brain functional connectivity in acute ischemic stroke patients and to explore the mechanism of action of XXMT. In total, 44 acute ischemic stroke patients were randomly divided to the XXMT treatment group (n = 22) or the placebo group (n = 22) in a 2-week trial. Before and after the treatment, the neurological assessment and functional magnetic resonance imaging examinations were carried out. Compared to the placebo group, the scores of the National Institutes of Health Stroke Scale (NIHSS) and Stroke-Specific Quality of Life Scale (SSQOL) significantly improved in the treatment group. In addition, XXMT-treated patients demonstrated significantly enhanced functional connectivity within the default mode, frontal-parietal, and motor control networks. Furthermore, the changed connectivity in the left precuneus was positively correlated to the improvement of NIHSS and SSQOL scores. The present study indicated that XXMT treatment significantly improved the neurologic deficit and quality of life of acute ischemic stroke patients and that the therapeutic effect may be based on the modulation of XXMT on the functional connectivity of brain networks.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Pattern of four networks in the XXMT treatment group and the placebo group was obtained by applying spatial ICA and one-sample t-test to the resting-state fMRI data. Abbreviation: aDMN, the anterior default mode network; pDMN, posterior default mode network; lFP, left frontal parietal network; and rFP, right frontal parietal network.
Figure 2
Figure 2
The interaction of group and time on the four networks was shown (P < 0.001, uncorrected). Abbreviation: aDMN, anterior default mode network; pDMN, posterior default mode network; lFP, left frontal parietal network; and rFP, right frontal parietal network.
Figure 3
Figure 3
The connection matrices of the six motor-related ROIs in the XXMT treatment group and the placebo group at baseline and at the second visit (2 weeks later) was shown (FDR correction, P < 0.05). (A) placebo-baseline; (B) placebo-2 weeks later; (C) treatment-baseline; D. treatment-2 weeks later. Abbreviation: M1.L, left primary motor cortex; M1.R, right primary motor cortex; pMC.L, left premotor cortex; pMC.R, right premotor cortex; SP.L, left superior parietal cortex; SP.R, right superior parietal cortex.
Figure 4
Figure 4
Correlations between changed connectivity of brain regions and changed values of common stroke scale scores in acute ischemic stroke patients.
Figure 5
Figure 5
The flow chart of the study.
See this image and copyright information in PMC

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