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. 2018 Apr;85(4):261-265.
doi: 10.1007/s12098-017-2509-8. Epub 2017 Nov 11.

Effects of Growth Hormone Treatment on Lipid Profiles

Toshihide Kubo  1 , Mahoko Furujo  2 , Kyohei Takahashi  2 , Yuki Hyodo  2 , Hiroki Tsuchiya  2 , Mariko Hattori  2 , Shoko Fujinaga  2 , Kenji Urayama  2
Affiliations

Effects of Growth Hormone Treatment on Lipid Profiles

Toshihide Kubo et al. Indian J Pediatr. 2018 Apr.

Abstract

Objectives: To assess the effects of growth hormone (GH) on lipid profiles in children and whether the effect is pharmacological.

Methods: The authors determined serum levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), and low-density lipoprotein cholesterol (LDL-C) every year during 3-y GH treatment in 48 GH deficient (GHD) short children and 22 children with short stature born small for gestational age (SGA).

Results: The abnormally high levels of TC, non-HDL-C, and LDL-C showed a high frequency in GHD short children compared with epidemiological studies in Japan. The high prevalence of high level of TC was also shown in SGA short children. Three-year GH treatment decreased serum TC, non-HDL-C, and LDL-C levels in both patient groups.

Conclusions: GH treatment is clearly a pharmacological therapy in SGA short children and so may also be in GHD short children at the Japanese standard therapeutic dose. Taken together, GH improves lipid profiles, and its effect has the possibility of medical properties.

Keywords: Cholesterol; Growth hormone; Growth hormone deficiency; Lipid; Small for gestational age.

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Comment in

  • Growth Hormone Therapy and Lipid Profile.
    Sharma R. Sharma R. Indian J Pediatr. 2018 Apr;85(4):253-254. doi: 10.1007/s12098-018-2638-8. Epub 2018 Feb 19. Indian J Pediatr. 2018. PMID: 29457205 No abstract available.

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