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Review
. 2017 Dec;37(4):895-913.
doi: 10.1016/j.cll.2017.07.013.

Flow Cytometric Evaluation of Primary Immunodeficiencies

Andreas Boldt  1 , Michael Bitar  2 , Ulrich Sack  2
Affiliations
Review

Flow Cytometric Evaluation of Primary Immunodeficiencies

Andreas Boldt et al. Clin Lab Med. 2017 Dec.

Abstract

Primary immunodeficiency diseases are genetic disorders that mostly cause susceptibility to infections and are sometimes associated with autoimmune and malignant diseases. For early detection and management of these diseases, flow cytometric procedures allow an encompassing assessment of cellular phenotypes and cellular functions. State-of-the art cytometry is based today on 8- to 10-color staining and includes an assessment of lineage maturation and functional markers.

Keywords: B-cell defect; Flow cytometry; Immunodeficiency; Immunophenotyping; T-cell defect.

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