Crystal structures of carboxypeptidase T complexes with transition-state analogs

Valery Kh Akparov¹, Vladimir I Timofeev^{2

3}, Ilyas G Khaliullin⁴, Vytas Švedas⁵, Inna P Kuranova^{2

3}, Tatiana V Rakitina^{3

6}

Affiliations

¹ a Protein Chemistry Department , State Research Institute for Genetics and Selection of Industrial Microorganisms , 1yi Dorozhnyi Proezd, 1, Moscow 117545 , Russia.
² b X-ray Analysis Methods and Synchrotron Radiation Laboratory , Shubnikov Institute of Crystallography of Federal Scientific Research Centre "Crystallography and Photonics" of Russian Academy of Sciences , Leninskii Prospect 59, Moscow 119333 , Russia.
³ c Kurchatov Complex of NBICS-Technologies , National Research Center "Kurchatov Institute" , Akad. Kurchatova pl.1, Moscow 123182 , Russia.
⁴ d Laboratory of Ion and Molecular Physics , Moscow Institute of Physics and Technology , Institutskii per., 9, Dolgoprudnyi, Moscow Region 141700 , Russia.
⁵ e Biokinetics Department , Lomonosov Moscow State University, Belozersky Institute of Physicochemical Biology , Leninskie Gory 1, b.73, Moscow 119991 , Russia.
⁶ f Laboratory of Hormonal Regulation Proteins, M.M. Shemyakin and Yu.A , Ovchinnikov Institute of Bioorganic Chemistry of Russian Academy of Sciences , ul. Miklukho-Maklaya 16/10, Moscow 117997 , Russia.

Valery Kh Akparov et al. J Biomol Struct Dyn. 2018 Nov.

. 2018 Nov;36(15):3958-3966.

doi: 10.1080/07391102.2017.1404932. Epub 2017 Nov 23.

Valery Kh Akparov¹, Vladimir I Timofeev^{2

3}, Ilyas G Khaliullin⁴, Vytas Švedas⁵, Inna P Kuranova^{2

3}, Tatiana V Rakitina^{3

6}

¹ a Protein Chemistry Department , State Research Institute for Genetics and Selection of Industrial Microorganisms , 1yi Dorozhnyi Proezd, 1, Moscow 117545 , Russia.
² b X-ray Analysis Methods and Synchrotron Radiation Laboratory , Shubnikov Institute of Crystallography of Federal Scientific Research Centre "Crystallography and Photonics" of Russian Academy of Sciences , Leninskii Prospect 59, Moscow 119333 , Russia.
³ c Kurchatov Complex of NBICS-Technologies , National Research Center "Kurchatov Institute" , Akad. Kurchatova pl.1, Moscow 123182 , Russia.
⁴ d Laboratory of Ion and Molecular Physics , Moscow Institute of Physics and Technology , Institutskii per., 9, Dolgoprudnyi, Moscow Region 141700 , Russia.
⁵ e Biokinetics Department , Lomonosov Moscow State University, Belozersky Institute of Physicochemical Biology , Leninskie Gory 1, b.73, Moscow 119991 , Russia.
⁶ f Laboratory of Hormonal Regulation Proteins, M.M. Shemyakin and Yu.A , Ovchinnikov Institute of Bioorganic Chemistry of Russian Academy of Sciences , ul. Miklukho-Maklaya 16/10, Moscow 117997 , Russia.

No abstract available

Cited by

The nature of the ligand's side chain interacting with the S1'-subsite of metallocarboxypeptidase T (from Thermoactinomyces vulgaris) determines the geometry of the tetrahedral transition complex.
Akparov VK, Timofeev VI, Konstantinova GE, Khaliullin IG, Kuranova IP, Rakitina TV, Švedas V. Akparov VK, et al. PLoS One. 2019 Dec 30;14(12):e0226636. doi: 10.1371/journal.pone.0226636. eCollection 2019. PLoS One. 2019. PMID: 31887148 Free PMC article.