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. 2018 Mar;141(3):1140-1141.e4.
doi: 10.1016/j.jaci.2017.10.016. Epub 2017 Nov 10.

Ventilation defect percent in helium-3 magnetic resonance imaging as a biomarker of severe outcomes in asthma

David G Mummy  1 , Stanley J Kruger  2 , Wei Zha  2 , Ronald L Sorkness  3 , Nizar N Jarjour  4 , Mark L Schiebler  5 , Loren C Denlinger  4 , Michael D Evans  6 , Sean B Fain  7
Affiliations

Ventilation defect percent in helium-3 magnetic resonance imaging as a biomarker of severe outcomes in asthma

David G Mummy et al. J Allergy Clin Immunol. 2018 Mar.

Abstract

Ventilation defect percent (VDP) measured in asthmatics with hyperpolarized helium-3 MRI was more strongly associated with ED visits and hospitalizations due to asthma exacerbation than were conventional biomarkers of lung function and inflammation.

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Figures

Figure 1
Figure 1
Whole lung ventilation defect percent (VDP) vs. outcome group in asthmatic subjects. VDP [median, interquartile range]: No ED or hospitalization (HOSP), [0.78, 1.77]; ED alone, [0.85, 2.95]; HOSP, [4.0, 3.86]. Shown above are typical images of hyperpolarized 3He MRI for subjects in corresponding outcome groups. Arrows indicate apparent ventilation defects. Ventilation defect percent (VDP): no ED or HOSP, 0.97%; ED alone, 1.93%; hospitalized, 6.53%.
Figure 2
Figure 2
Gradient boosting machine results showing ventilation defect percent (VDP) with highest relative influence over other factors in predicting severe outcomes. EOS – eosinophil; RV – residual volume; TLC – total lung capacity; PP – percent predicted; FEV1 – forced expiratory volume in one second; FVC – forced vital capacity; MAC – macrophage; PMN – neutrophil.
See this image and copyright information in PMC

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