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Comment
. 2017 Nov:25:20-21.
doi: 10.1016/j.ebiom.2017.10.031. Epub 2017 Nov 10.

Dual Mechanisms for Balancing Th17 and Treg Cell Fate by CREB

Antony Symons  1 , Wenjun Ouyang  2
Affiliations
Comment

Dual Mechanisms for Balancing Th17 and Treg Cell Fate by CREB

Antony Symons et al. EBioMedicine. 2017 Nov.

Abstract

Th17 cells, which express the cytokine IL-17A, and master regulator RORγt, are important in the inflammatory response to fungal and bacterial pathogens, but also have a pathogenic role in many inflammatory disorders. In contrast, regulatory T cells (Treg), expressing the Foxp3 transcription factor, have a suppressive function and can dampen an immune response. The appropriate balance of these distinct effector functions is critical for an effective immune response and autoimmunity can arise if this process goes awry. In this issue, Wang et al. demonstrate a critical role for the transcription factor CREB (cyclic AMP-responsive element binding protein) in regulating the balance between inflammatory Th17 and suppressive Treg cells with implications for autoimmunity.

Keywords: CREB; Regulatory T cells; Th17 cells.

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References

    1. Altarejos J.Y., Montminy M. CREB and the CRTC co-activators: sensors for hormonal and metabolic signals. Nat. Rev. Mol. Cell Biol. 2011;12:141–151. - PMC - PubMed
    1. Boniface K., Bak-Jensen K.S., LI Y., Blumenschein W.M., Mcgeachy M.J., Mcclanahan T.K., Mckenzie B.S., Kastelein R.A., Cua D.J., De Waal Malefyt R. Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling. J. Exp. Med. 2009;206:535–548. - PMC - PubMed
    1. Kim H.P., Leonard W.J. CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation. J. Exp. Med. 2007;204:1543–1551. - PMC - PubMed
    1. Korn T., Bettelli E., Oukka M., Kuchroo V.K. IL-17 and Th17 Cells. Annu. Rev. Immunol. 2009;27:485–517. - PubMed
    1. Rutz S., Eidenschenk C., Kiefer J.R., Ouyang W. Post-translational regulation of RORgammat-A therapeutic target for the modulation of interleukin-17-mediated responses in autoimmune diseases. Cytokine Growth Factor Rev. 2016;30:1–17. - PubMed

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