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Case Reports
. 2018 Jul 10;17(3):269-272.
doi: 10.2463/mrms.cr.2017-0111. Epub 2017 Nov 13.

Spatial Restriction within Intracranial Epidermoid Cysts Observed Using Short Diffusion-time Diffusion-weighted Imaging

Christina Andica  1 , Masaaki Hori  1 , Kouhei Kamiya  2 , Saori Koshino  1   2 , Akifumi Hagiwara  1   2 , Koji Kamagata  1 , Issei Fukunaga  1 , Nozomi Hamasaki  1 , Michimasa Suzuki  1 , Thorsten Feiweier  3 , Katsutoshi Murata  4 , Atsushi Arakawa  5 , Akihide Kondo  6 , Osamu Akiyama  6 , Shigeki Aoki  1
Affiliations
Case Reports

Spatial Restriction within Intracranial Epidermoid Cysts Observed Using Short Diffusion-time Diffusion-weighted Imaging

Christina Andica et al. Magn Reson Med Sci. .

Abstract

We report two cases of pathologically proven intracranial epidermoid cysts. Both cases were scanned with diffusion-weighted imaging using pulsed gradient spin-echo (PGSE) and oscillating gradient spin-echo (OGSE; 50 Hz) prototype sequences with diffusion times of 47.3 ms and 8.5 ms, respectively. The apparent diffusion coefficient measured by OGSE was higher than that measured by PGSE, indicating the spatial restriction of water diffusion in the laminated keratin layers within the cyst as demonstrated by histopathology.

Keywords: diffusion-weighted imaging; epidermoid cyst; oscillating gradient spin-echo; restricted diffusion; tissue microstructure.

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Conflict of interest statement

Conflicts of Interest

Thorsten Feiweier is an employee of Siemens Healthcare GmbH, Erlangen Germany and Katsutoshi Murata is an employee of Siemens Healthcare K.K., Japan. All remaining authors declare no conflicts of interest associated with this manuscript.

Figures

Fig. 1
Fig. 1
Diffusion-weighted imaging (DWI) of epidermoid cysts from patients I and II. Each column displays images in the following order: pulsed gradient spin-echo (PGSE) trace DWI, PGSE apparent diffusion coefficient (ADC) map, oscillating gradient spin-echo (OGSE) trace DWI, and OGSE ADC map. Epidermoid cysts (arrows) appear as hyperintense lesions on PGSE and OGSE DWI. ADC maps show a lower ADC on PGSE and a higher ADC on OGSE.
Fig. 2
Fig. 2
Photomicrographs of epidermoid cysts with a squamous epithelial lining from patients I (a) and II (b) are shown. Laminated keratin layers separated by interstitium are seen beneath the epithelial lining. Hematoxylin and eosin (H&E) stain, ×200.
See this image and copyright information in PMC

References

    1. Baron CA, Beaulieu C. Oscillating gradient spin-echo (OGSE) diffusion tensor imaging of the human brain. Magn Reson Med 2014; 72:726–736. - PubMed
    1. Does MD, Parsons EC, Gore JC. Oscillating gradient measurements of water diffusion in normal and globally ischemic rat brain. Magn Reson Med 2003; 49:206–215. - PubMed
    1. Hori M, Irie R, Suzuki M, Aoki S. Teaching neuroimages: obscured cerebral infarction on MRI. Clin Neuroradiol 2017; doi: 10.1007s00062-017-0576-x [Epub ahead of print] - PMC - PubMed
    1. Wu D, Martin LJ, Northington FJ, Zhang J. Oscillating gradient diffusion MRI reveals unique microstructural information in normal and hypoxia-ischemia injured mouse brains. Magn Reson Med 2014; 72:1366–1374. - PMC - PubMed
    1. Colvin DC, Yankeelov TE, Does MD, Yue Z, Quarles C, Gore JC. New insights into tumor microstructure using temporal diffusion spectroscopy. Cancer Res 2008; 68: 5941–5947. - PMC - PubMed

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